Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

The crystal structure of bis{3-(diphenylphosphaneyl)propanoato-κ2 O,P}platinum(II) dihydrate, C30H28O6P2Pt

“…The connectivity in the title compound together with the bond lengths and bond angles are in expected ranges. The Pt-O and Pt-P bond lengths are 2.0744 Å and 2.2242 Å, respectively which is similar to what has been reported in literature [17][18][19][20].…”

Synthesis, Characterization, andin vitroCytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

“…Previous structural studies on gold(I) complexes with amino/imino‐phosphines reveal that the central gold atoms in these complexes are usually coordinated only by phosphorus atoms adopting a linear environment. The nitrogen atom does not bind to the metal atom , , . Therefore, it is expected that the most probable structures of complex 1 and 2 are those shown in Scheme .…”

“…In recent years, an increasing number of gold(I)‐phosphine complexes have shown to display potent anti‐cancer activities , . However, the reports on cytotoxic properties of gold(I) complexes containing mixed P,N type ligands are limited , . Several mixed ligand gold(I) complexes of phosphines and dithiocarbamates have also been evaluated for the antitumor activity against a number of cells .…”

Synthesis of Gold(I) Complexes Bearing Verkade's Superbases

“…Computational Treatment: Calculations were performed at the TPSS level[18a] by using a relativistic effective core potential for gold[15c] and the def2‐TZVP basis set. [18b] The resolution of identity technique was employed .…”

“…This should make Verkade's superbases interesting alternatives to phosphines and NHC ligands for the stabilization of transition metals. Gold(I) complexes of NHC ligands in the recent past have become very important in the field of bioorganometallic chemistry and homogeneous catalysis . Herein, we disclose our theoretical and experimental investigations of the coordination properties of proazaphosphatranes with gold(I).…”