Synthesis, characterisation and insulin-mimetic activity of oxovanadium(IV) complexes with amidrazone derivatives

Cocco, Maria Teresa; Onnis, Valentina; Ponticelli, G.; Meier, Beate; Rehder, Dieter; Garribba, Eugenio; Micera, Giovanni

doi:10.1016/j.jinorgbio.2006.07.015

Cited by 38 publications

(16 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The preparation of amidrazones was reported by different methods such as addition of sodium hydrazide to nitriles [10], reaction of nitrohydrazones with amines [11], and enzymatic methodologies [12]. Amidrazones can be used as versatile ligands and their complexes were shown antibacterial [13], antitumor [14], and insulin-mimetic activities [15]. The importance of amidrazones revealed more when their anticancer [16,17] and enzymatic inhibitory [18,19] properties were observed.…”

Section: Introductionmentioning

confidence: 99%

DFT and MP2 study of simple and water-assisted tautomerism in amidrazones

Tavakol

2011

Struct Chem

View full text Add to dashboard Cite

DFT and MP2 methods were used to calculate structural parameters, vibrational modes, solvent effect, and energetic properties of amidrazones. Amidrazones can be presented by three tautomeric forms and six isomers. All tautomers and transition states were optimized at the B3LYP/6-311??g** and MP2/6-311??G** levels of theory. The relative stabilities of amidrazone isomers in the gas phase were found to be as 1Z. The calculated energy differences between E and Z isomers are very low and between different tautomers are nearly low, but the energy barriers for tautomerism interconversions at the gas phase are high. The kinetic and thermodynamic data in solvents (chloroform, tetrahydrofuran, acetone, and water) are nearly similar to those in the gas phase but their rate constants are slightly less than those in the gas phase. Moreover, equilibrium and rate constants of intermolecular tautomerism in presence of 1-3 molecules of water were calculated. Computed energy barriers show that the barrier energy of water-assisted tautomerism is very lower than that in simple tautomerism and also calculated binding energies show that water can stabilize transition states more than tautomers. Therefore, this water-assisted tautomerism can be performed fast, especially with the assistance of two molecules of water.

show abstract

Section: Introductionmentioning

confidence: 99%

DFT and MP2 study of simple and water-assisted tautomerism in amidrazones

Tavakol

2011

Struct Chem

View full text Add to dashboard Cite

show abstract

“…Work reported by Heyliger et al [8] in 1985 was the first to show that vanadate normalized hyperglycemia in vivo in animals; this was subsequently confirmed by Meyerovitch et al [9]. Since then, extensive studies exploring vanadium chemistry [10][11][12][13][14][15][16][17]. In addition to glucose lowering effects, certain vanadium complexes in þ4 and þ5 oxidation states exhibit antimicrobial activity [18][19][20].…”

Section: Introductionmentioning

confidence: 94%

Synthesis, spectral characterization, and antidiabetic study of new furan-based vanadium(IV) complexes

Sheela

Vijayaraghavan

2011

Journal of Coordination Chemistry

View full text Add to dashboard Cite

“…They react with a wide range of transition metals in their neutral or ionic forms and they show a diversity of coordination modes [21,22], which can lead to complexes having different geometries and various molecular arrangements. These properties made them useful in design and synthesis of novel functional materials [23,24].…”

Section: Introductionmentioning

confidence: 99%

“…These properties made them useful in design and synthesis of novel functional materials [23,24]. Furthermore, amidrazone derivatives are of interest as ligands in medicinal chemistry following the reports on antitumor properties of their Cu(II), Au(III) and Pt(II) complexes [25][26][27] or antibacterial [28,29], antimalarial [30] and insulinmimetic activities [22] of many other 3d transition metal complexes.…”

Section: Introductionmentioning

confidence: 99%