Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents

Priya M, Gnana R.; Devhare, Lalchand D.; Dharmamoorthy, G.; Khairnar, Mahendra V.; Prasidha, R.

doi:10.25258/ijpqa.14.3.03

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The equation y = mx + c, with r as the correlation coefficient, y representing peak area ratio, and x being the drug concentration in ng/mL, was used to derive the mean calibration curve. 26 The result was collected and calculated using a software analyzer on the Shimadzu controlled. Linear regression was utilized to find the data with the greatest fit for the calibration curves.…”

Section: Sample Preparation 24mentioning

confidence: 99%

Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

Chauhan,

Singh,

Singh

et al. 2024

IJPQA

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This research aimed to prepare and assess an aloin nanoparticle that might increase its oral bioavailability. Utilizing the nanoprecipitation process, aloin Poly lactic-co-glycolic acid (PLGA) nanoparticulate was formulated and studied for the best strategy based on their characteristics and in-vitro release. The aloin nanoparticle stability research was evaluated at room temperature for a duration of three months. Additionally, pharmacokinetic (PK) tests were analyzed by using various parameters and experiments done by taking female wistar albino rats, with weights of approximately (150–200 gm). The animal was appropriately given the proper housing according to the protocol and placed in a period of twelve hours day and night. The drug was administered for 72 hours at a dosage of 10 mg/kg. of all the aloin nanoformulations developed, the one with the best size of particles was 98.5 nm with an entanglement efficacy of 98.09%. The results show that when compared to pure aloin, aloin PLGA nanoparticulate has a higher bioavailability.

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Section: Sample Preparation 24mentioning

confidence: 99%

Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

Chauhan,

Singh,

Singh

et al. 2024

IJPQA

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“…The government has to provide a health care funding, improve the primary health care systems and tolerating non-communicable disease patients and conduct programmes to get awareness about chronic kidney disease. [25][26][27]…”

mentioning

confidence: 99%

To Evaluate the Epidemiology, Etiology, Risk Factors and Treatment Management in Chronic Kidney Disease in Children, Adult and Geriatric Patients in a Tertiary Care Teaching Hospital in Nellore

Darwin

2023

IJPQA

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Chronic renal failure is a life-threatening disease to society. The study was conducted from October 2021 to June 2023 the study was done in the Nephrology inpatient ward, Vijaya Super Speciality Hospital, Pogathota Nellore, Andhra Pradesh. The study design is a cross-sectional for epidemiology and prospective observational study-1 for etiology, II-risk factors, III-treatment management. The sample size are 381 subjects in that children are 51 subjects, adult 171 subjects and geriatric are 159 subjects. The male are 199 volunteers and the female are 182 volunteers with chronic kidney disease (CKD). The result of this study was the epidemiology factor more in adults (45%) when compared to children (13%) and geriatrics (42%). In the sex parameters are less affected to females (48%) and males (52%) are more affected with chronic kidney disease. The etiology causes in children are glomerulonephritis, adults diabetes mellitus (DM) and geriatrics pyelonephritis these are the main causes for chronic renal disease when compared to other etiological causes. Risk factors in children are congenital defects, adult are diabetes mellitus and geriatric are kidney disease these are the risk factors to the renal failure patients. In treatment management, hemodialysis is the most effective treatment to adults when compared to children’s and geriatric eng stage renal failure disease. The conclusion of this study initially may rectify causes and risk factors of the patients may not high prevalent in end-stage renal failure disease it not cause hemodialysis therapy and renal transplantation in children, adults and geriatric patients.

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Deciphering the Lexicon of Protein Targets: A Review on Multifaceted Drug Discovery in the Era of Artificial Intelligence

Nandi,

Bhaduri,

Das

et al. 2024

Mol. Pharmaceutics

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Understanding protein sequence and structure is essential for understanding protein−protein interactions (PPIs), which are essential for many biological processes and diseases. Targeting protein binding hot spots, which regulate signaling and growth, with rational drug design is promising. Rational drug design uses structural data and computational tools to study protein binding sites and protein interfaces to design inhibitors that can change these interactions, thereby potentially leading to therapeutic approaches. Artificial intelligence (AI), such as machine learning (ML) and deep learning (DL), has advanced drug discovery and design by providing computational resources and methods. Quantum chemistry is essential for drug reactivity, toxicology, drug screening, and quantitative structure−activity relationship (QSAR) properties. This review discusses the methodologies and challenges of identifying and characterizing hot spots and binding sites. It also explores the strategies and applications of artificial-intelligence-based rational drug design technologies that target proteins and protein−protein interaction (PPI) binding hot spots. It provides valuable insights for drug design with therapeutic implications. We have also demonstrated the pathological conditions of heat shock protein 27 (HSP27) and matrix metallopoproteinases (MMP2 and MMP9) and designed inhibitors of these proteins using the drug discovery paradigm in a case study on the discovery of drug molecules for cancer treatment. Additionally, the implications of benzothiazole derivatives for anticancer drug design and discovery are deliberated.

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Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents

Cited by 3 publications

References 10 publications

Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

To Evaluate the Epidemiology, Etiology, Risk Factors and Treatment Management in Chronic Kidney Disease in Children, Adult and Geriatric Patients in a Tertiary Care Teaching Hospital in Nellore

Deciphering the Lexicon of Protein Targets: A Review on Multifaceted Drug Discovery in the Era of Artificial Intelligence

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