Synthesis, Characterisations, Lipid Lowering Activity and Antibacterial Activities of Some Benzoyl Ester Substituted Embelin Derivatives

Abstract

The research article represents the extraction of Embelin from its plant source and synthesis, characterisation, lipid lowering activities and antibacterial studies of some Benzoyl ester substituted derivatives of Embelin. The derivatives of Embelin, EL -1 to EL -5 were prepared by treating Embelin with Meta and Para substituted benzoyl chloride in presence of base pyridine and dichloromethane. Benzoyl ester substituted derivatives of Embelin molecule also shows more or less medicinal properties then the parent Embelin molecule. The synthesized compound were characterised and identified on the basis of elemental analysis, UV, FTIR, Mass and NMR spectroscopy and their antibacterial activities were studied against test organism viz B. subtilis gram positive, S.aureus Gram positive, C.Albicans Antifungal and E.coli Gram negative. The lipid lowering activities of prepared compound were also studied in percentage on pancreatic lipase inhibition simply on the basis of change in international unit (IU).

Thermodynamics of Ion Exchange Reaction in Predicting the Ionic Selectivity Behavior of UV Radiation Degraded Nuclear-grade and Non-nuclear Grade Resins

“…In order to remove or separate radio nuclides and other ions from industrial waste it was very difficult to choose the suitable ion exchange resins for the separations of these ions so that there was need of some thermodynamic data or techniques which will provides the useful information about the various nuclear and industrial grade resins and helps to select which of the ion exchange resins were suitable for removal or separations of various cations and anions from industrial waste and nuclear waste. Taking in to the considerations and needs of industries attempts were made in the present research study to evaluate the performance 6 of two closely related resins viz Duolite ARA9366 and Duolite A-378 under stringent degradation conditions like UV radiation of different wavelength in a UV chamber 7 for 24 h separately for the resins and thermodynamic ion exchange equilibrium studies were carried out in predicting the selectivity behavior of these resins in chloride form towards the iodide ions of different ionic concentrations under the temperature range of 30.0 -45.0 o C for 5 h the thermodynamic data obtained from the study will helpful in predicting the selectivity behavior of the resins. The data obtained from the study will also be helpful for the selection of suitable ion exchange resin under the stringent degradation like UV radiations.…”