Synthesis, characterization &amp; biological studies of Mn(II), Fe(III) and Co(II) complexes of (Z)-1, 5-dimethyl-4-(2-(2-oxopropylidene) hydrazinyl)-2-phenyl-1H-pyrazol-3(2H)-one

Sreepriya, R.S.; Kumar, Shubha S.; Sadasivan,; Biju, S.; Meena, Sher Singh

doi:10.1016/j.molstruc.2019.127110

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…This finding demonstrates that hydrazone 1 is present in keto-enol tautomerization (Supporting Information Figure S3). The proton of the azomethine group H- 17 C=N was seen as a singlet at δ = 8.84 ppm while the aromatic protons can be observed in the 7.06-8.32 ppm range. The signal characteristic for the methylene (O-CH 2 ) group appeared as a singlet at 3.38 ppm.…”

Section: Biocidal Activitiesmentioning

confidence: 98%

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

El‐Saied

Shakdofa

Al‐Hakimi

et al. 2020

Applied Organom Chemis

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complexes of a synthetic novel hydrazone containing a quinoline moiety were prepared. The composition and structure of the prepared compounds were elucidated by spectral and analytical techniques. The results reveal that all complexes were formed in 1:1 mole ratio except Mn 2+ and Cu 2+ complexes (3) and (7), which were formed in 1 M:2 L mole ratio. It was also found that the ligand binds the metal ions via NO donor sites as a monobasic bidentate chelator in all complexes through the enolic carbonyl oxygen and azomethine nitrogen atoms. The electronic absorption spectra and magnetic moment data demonstrated square pyramidal and octahedral geometries for the VO 2+ and Ni 2+ complexes, respectively, while the other complexes adopted tetrahedral geometry. The thermal decomposition of the complexes was discussed in relation to structure. The thermal analysis data demonstrated that all complexes were decomposed in one, two, three or four stages starting with the dehydration process, removal of coordination water molecules or elimination of anions and ended with the formation of the metal oxide. The bactericidal activities of the prepared compounds demonstrated that hydrazone (1) exerted a highly inhibitory effect against B. subtilis while VO 2+ , Co 2+ , and Cu 2+ complexes (2), (4), and (7) showed an inhibitory effect against E. coli more than the tetracycline. Additionally, the inhibitory effect of the prepared compound against A. niger showed that the Cu 2+ complex (6) is the most active while the Ni 2+ , Cu 2+ , and Zn 2+ complexes (5-8) exhibited an extremely inhibitory effect against C. albicans.

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Section: Biocidal Activitiesmentioning

confidence: 98%

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

El‐Saied

Shakdofa

Al‐Hakimi

et al. 2020

Applied Organom Chemis

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“…Sreepriya et al . [ 49 ] prepared a series of manganese(II) complex 158 , cobalt(II) complex 159 and iron(III) complex 160 by reacting the respective metal chlorides with a 4-aminoantipyrine derivative. The ligand was prepared by treating the diazonium salt of 4-aminoantipyrine with 3-oxobutanoic acid.…”

Section: Transition Metal Complexes Of 4-aminoantipyrine Derivatives ...mentioning

confidence: 99%

“… Interaction of the ligand with native form of HIV Reverse Transcriptase with PDB ID (a) 1RT2 and (b) 1FK9; mutant form of HIV Reverse Transcriptase with PDB ID (c) 3BGR and (d) 1JLB (adapted from [ 49 ]). …”

Section: Transition Metal Complexes Of 4-aminoantipyrine Derivatives ...mentioning

confidence: 99%

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

et al. 2022

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Transition metal complexes of 4-aminoantipyrine derivatives have been gaining great interest due to their rich coordination chemistry and potential applications in the field of pharmaceutical science. The presence of a free amine and a cyclic ketone functionality makes 4-aminoantipyrine an attractive amphoteric substrate for Schiff base formation. Varieties of aldehydes/ketones or amines of versatile steric, electronic and functional nature could be condensed with the 4-aminoantipyrine motif to obtain the ligand systems of multi-denticity and diverse coordination behaviour. The transition metal complexes obtained from these ligand systems exhibit unique structural and functional properties. This review compiles the important transition metal complexes developed from the Schiff base derivatives of 4-aminoantipyrine, and their utility as antibacterial and antifungal agents. Rationale of the strategies involved in the development of highly potential antimicrobial agents is discussed.

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“…ese applications are signi cant because of the wide range of their pharmacokinetic properties [2][3][4][5], especially their importance in drug detection programs [6,7]. Numerous studies have con rmed that the hydrazone and carbaldehyde derivatives and their complexes have a wide series of biological properties [8][9][10][11], such as anticancer [12][13][14][15], antibacterial [16][17][18], antimicrobial [19][20][21], antifungal [22,23], antimalarial [24], antiviral [25], antimycobacterial [12,26], antileishmanial [25,27], antiplatelet [28], antianalgesic, antitubercular, anticonvulsant [29], antiuropathogenic [30], antiproliferative [31], antiarthritic [32], and antioxidant [33][34][35] properties and are potent immunomodulatory agents [36] and antiangiogenic agents in atherosclerosis [33]. Moreover, they play an important role in treating Alzheimer's disease [37,38].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, PXRD Studies, Theoretical Calculation, and Antitumor Potency Studies of a Novel N,O‐Multidentate Chelating Ligand and Its Zr(IV), V(IV), Ru(III), and Cd(II) Complexes

Elganzory

Hassan

Aly

et al. 2022

Bioinorganic Chemistry and Applications

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A new series of Zr(IV), V(IV), Ru(III), and Cd(II) complexes with the ligand N-((5-hydroxy-4-oxo-4H-pyran-3-yl)methylene)-2-(p-tolylamino)acetohydrazide (H2L) have been prepared. FT-IR, 1H-NMR, electronic spectra, powder X-ray, and thermal behavior methods were applied to elucidate the structural composition of new compounds. Geometry optimization for all synthesized compounds was conducted using the Gaussian09 program via the DFT method, to obtain optimal structures and essential parameters. Moreover, the antibacterial and antitumor activity of the ligand and its complexes were studied, where the Cd(II) complex acquires probably the best antibacterial activity followed by the Ru(III) complex towards bacterial species than others when using ampicillin and gentamicin were used as standard drugs. The complexes exhibited interestingly antitumor potential against the MCF-7 breast cancer cell line. The cytotoxicity of the new complexes has been arranged to follow the order: Ru(III) complex > Cd(II) complex > Zr(IV) complex > V(IV) complex > ligand. Molecular docking was performed on the active site of ribosyltransferase and obtained good results. Structure-based molecular docking is used to identify a potential therapeutic inhibitor for NUDT5.

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Synthesis, characterization & biological studies of Mn(II), Fe(III) and Co(II) complexes of (Z)-1, 5-dimethyl-4-(2-(2-oxopropylidene) hydrazinyl)-2-phenyl-1H-pyrazol-3(2H)-one

Cited by 11 publications

References 14 publications

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

Synthesis, Characterization, PXRD Studies, Theoretical Calculation, and Antitumor Potency Studies of a Novel N,O‐Multidentate Chelating Ligand and Its Zr(IV), V(IV), Ru(III), and Cd(II) Complexes

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