Synthesis, characterization, and 3D-molecular modeling and analysis of some copper(II) chelates in O, N-donor coordination pattern involving Schiff bases derived from 4-butyryl-3-methyl-1-phenyl-2-pyrazolin-5-one and some sulfa drugs

Maurya, R. C.; Jhamb, Sarbjit Singh; Roy, Souvik; Chourasia, J.; Sharma, Arun; Vishwakarma, P.K.

doi:10.1016/j.arabjc.2011.01.015

Cited by 10 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a few values of optimal bond lengths /angles were lost, this may be attributed to the limitations of the software, which was observed in modelling of other systems [51]. In most of the previous studies, the calculated bond angles and lengths are near to the optimal values [51,52]. Consequently, the proposed structure of the Co(II) complex (1) and other complexes are acceptable.…”

Section: D Molecular Modelling Studiesmentioning

confidence: 99%

Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes

El‐Boraey

El-Din

EL-Gammal³

2021

Egypt. J. Chem.

View full text Add to dashboard Cite

In the present study, new Co(II), Ni(II) and Cu(II) complexes were synthesized from the reaction of tetradentate Schiff's base ligand (H2L)= (N, N'-(pyridine-2,6-diyl) bis (2-(((Z)-(2-hydroxynaphthalen-1-yl) methylene) amino) benzamide that was synthesized via condensation of 2-amino-N-{2-[(2-amino-benzoylamino) pyridine]-benzamide} with 2-hydroxy-1naphthaldehyde. The ligand and its metal (II) complexes were characterized by microanalyses, magnetic, spectral, powder Xray diffraction (XRD) and thermal studies. An octahedral geometry has been proposed for [Co(L)(H2O)2].3H2O (1), [Ni(L)(H2O)2].1½H2O (2) and square planar for [Cu(L)](3) and [Cu(H2L)(OH)Br](4). EPR spectra of Cu(II) complexes are consistent with dx²-y² ground state. 3D molecular modeling studies have been carried out for ligand and complex (1). Average crystallite size (D) and dislocation density (δ) were calculated from XRD. All compounds were screened for their in vitro antioxidant activity. The results showed that the ligand possesses excellent activity compared to the reference (Ascorbic acid) and complex (4) was the most potent one. Moreover, the current compounds were tested for their antimicrobial activity.

show abstract

Section: D Molecular Modelling Studiesmentioning

confidence: 99%

Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes

El‐Boraey

El-Din

EL-Gammal³

2021

Egypt. J. Chem.

View full text Add to dashboard Cite

show abstract

“…A yellowish brown solid of benzoyl derivative (bmphp) (Figure 2) settled. This was collected on the sintered glass crucible, washed with distilled water and then dried in vacuo 18 .…”

Section: Preparation Of Benzoyl Derivative Of 3-methyl-1phenyl-2-pyramentioning

confidence: 99%

Untitled

2014

IJPSR

View full text Add to dashboard Cite

The novel Co (II) and Zn (II) complexes have been synthesized by reaction of CoCl 2 /ZnCl 2 with Schiff bases of benzoyl derivative of 3-methyl-1-phenyl-2-pyrazoline-5-one and sulfa drugs in 1:2 ratio. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. E. coli, Staphylococcus aureus strain I, Staphylococcus aureus strain II, Staphylococcus aureus strain III, Vibrio cholera, Gram positive Cocci, Gra am positive Bacillus, Gram negative Bacillus, Bacillus subtilis and Salmonella typhimurium. It was found that metal complexes have more antimicrobial activity than their parent Schiff bases. Complexes of Schiff base ligand sulfamerazine and bmphp (L 2) were also found to be more active. INTRODUCTION: Schiff bases containing azomethine (imine) group (-RC=N-) are usually prepared by the condensation of a primary amine with an active carbonyl compound 1, 2. The formation of variety of metal complexes with such ligands, indicate the spectacular progress in coordination and bioinorganic chemistry. Schiff base complexes of transition metals containing ligand with N, O donors exhibit interesting biological activity. It has now been observed that some of these drugs show increased biological activity when administered in the form of metal complexes 3, 4 .

show abstract

“…Schiff base metal complexes have a wide interest in clinical, biological and analytical applications [4].They show biological activities including anti bacterial, anti fungal, anti cancer and herbicidal activities, anti-tubercular activities [5]. Moreover, some metal complexes of these ligands have been found to promote rapid healing of burns in humans and animals [6]. The current study investigated the preparation and properties of some metal ion complexes with sulfamethoxazole derivatives.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Cu (II), Mn(II) and Zn(II)complexes with new sulfamethoxazole Compounds

Journal¹

2017

Baghdad Sci.J

View full text Add to dashboard Cite

Acetophenone sulfamethoxazole and 3-Nitrobenzophenone sulfamethoxazole were prepared from the reaction of sulfamethoxazole with two ketones. The prepared ligands were identified by (C.H.N) analysis and UV-VIS, FT-IR spectroscopic techniques. Metal complexes of the two ligands were prepared in an aqueous alcohol with Zn (II), Mn (II) and Cu (II) ions with a molar ratio1:1. The proposed general formula for the resulting complexes was [ML.CL2.H2O]H2O .The complexes were characterized by (C.H.N) technique , spectroscopic methods ,conductivity, atomic absorption ,magnetic susceptibility measurements and melting point. According to the results obtained, the suggested geometry is to be octahedral for all the complexes.

show abstract

Synthesis, characterization, and 3D-molecular modeling and analysis of some copper(II) chelates in O, N-donor coordination pattern involving Schiff bases derived from 4-butyryl-3-methyl-1-phenyl-2-pyrazolin-5-one and some sulfa drugs

Cited by 10 publications

References 44 publications

Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes

Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes

Untitled

Preparation and Characterization of Cu (II), Mn(II) and Zn(II)complexes with new sulfamethoxazole Compounds

Contact Info

Product

Resources

About