Synthesis, characterization and anti-inflammatory activity evaluation of 1,2,4-triazole and its derivatives as a potential scaffold for the synthesis of drugs against prostaglandin-endoperoxide synthase

Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties

“…The great attention paid by researchers to the study of quinoline derivatives is explained by their broad range of biological activities, such as anti-Alzheimer [9], antidiabetic [10], anti-inflammatory [11], antituberculosis [12], anticancer [13], antioxidant [14], and as inhibitors of SARS-CoV-2 (COVID-19) virus [15][16][17]. Therefore, compounds containing thiazole heterocycles are well known in medicinal chemistry [18], thiazole derivatives exhibit significant biological activities, such as antimicrobial and antimalarial [19], Alzheimer [20], antiproliferative agents [21], anticancer agents [22], and anti-inflammatory [23]. In addition, coumarins are an important class of heterocyclic compounds with various biological activities [24].…”

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

“…But the relevance of creating compounds with anti-cancer activity encourages us to move on to the practical part as soon as possible. Therefore in studies [32,[35][36][37][38][39][40] described the anti-cancer and anti-tumor activities of already synthesized compounds.…”

An insight on medicinal attributes of 1,2,4-triazoles

“…46 ) was evaluated for radical scavenging and anti-inflammatory activities in vitro and in vivo by Khan et al. [ 213 ]. The most potent compound 241a with 64.44% inhibition of edema and a potency of 0.92 at 20 mg/kg body weight after 5 h of inducing inflammation was comparable to reference indomethacin (potency 1.00).…”