Synthesis, Characterization and Antibacterial Activity of some Hg(II) Complexes with Mixed Benzyl 2-(2-oxoindolin-3-ylidene) Hydrazinecarbodithioate and Phosphines or Amines Ligands

Abstract

activity. 15,16 The anticancer evaluation of a substantial number of metal complexes containing isatin-based ligands has been described as antitumor compounds, especially Mg(II), Co(II), Ni(II), and Cu(II) complexes, with different coordination geometries and reactivities. 17 Materials and MethodsAll the chemicals, reagents and solvents for the synthesis of compounds were supplied and used without more purification. The melting point of the prepared complexes was recorded on Automatic (SMP30) melting point apparatus. The molar conductivity of 10 -3 M freshly DMSO solution of prepared complexes was measured using (Starter 3100c) digital conductivity meter at 25 o C. Microanalyses for carbon, hydrogen, nitrogen and sulfur were carried out using an Elementar vario El III CHN elemental analyzer. The IR spectra of the prepared complexes as KBr pellets were recorded using a Shimadzu FT-IR 8400S spectrophotometer (400-4000 cm -1 ). NMR spectra were acquired on a Bruker 400 MHz spectrometer in DMSO-d6 as a solvent. The isolates of the pathological bacteria that were used in the research obtained from the laboratories of the Department of Life Sciences in the College of Education for Pure Sciences at the University of Tikrit. Preparation of benzyl 2-(2-oxoindolin-3-ylidene)hydrazinecarbodithioate (BHT) ligandThe benzyl 2-(2-oxoindolin-3-ylidene)hydrazinecarbodithioate (BHT) Prepared by two steps: First step: Preparation of S-Benzyldithiocarbazate (SBDTC). This compound was synthesized as previously reported, 18 the melting point was 124 o C where it was at 124-125 o C in the literature. 19 Second step: To the hot solution of S-benzyldithiocarbazate, SBDTC (1.36g, 0.01 mol) in ethanol (35 mL), an equimolar amount of isatin

Synthesis and Structural Characterization of Palladium(II) Mixed-Ligand Complexes of N-(Benzothiazol-2-yl)benzamide and 1,2-Bis(diphenylphosphino)ethane

“…The 31 P NMR spectra of complexes 1 and 2 each exhibited an AX spin system with two doublets each at δP = 43.89 and 33.93 ppm and 54.65 and 37.66 ppm, which indicates that the two phosphorus atoms are nonequivalent; that is, one phosphorus atom is trans to the oxygen atom and the other phosphorus atom is trans to the nitrogen atom, in the square-planar configuration around the palladium­(II) ion, , whereas the spectrum of complex 3 showed a singlet at δP = 57.70 ppm, indicating two equivalent phosphorus atoms that are trans to the nitrogen atom in the ligand L.…”

“…The 31 P NMR spectra of complexes 1 and 2 each exhibited an AX spin system with two doublets each at δP = 43.89 and 33.93 ppm and 54.65 and 37.66 ppm, which indicates that the two phosphorus atoms are nonequivalent; that is, one phosphorus atom is trans to the oxygen atom and the other phosphorus atom is trans to the nitrogen atom, in the squareplanar configuration around the palladium(II) ion, 23,24 whereas S1−S3. An unexpected novel feature of the structure is transfer of the negative charge from the nitrogen atom of the amide group to form a double bond with the carbon atom of the thiazole ring, thus converting the double bond of the thiazole ring into a negative charge on the nitrogen atom of the thiazole ring (Figure 2), which is bonded to palladium by a covalent bond (Pd1−N1 bond length: 2.110 Å) and (Pd1−N2 bond length: 2.102 Å).…”

“…22 The ν(P−Ar) bands of complexes 1−3 appeared at 1431, 1431, and 1434 cm −1 , respectively, whereas the corresponding ν(P−C) bands appeared at 1099, 1103, and 1105 cm −1 . 23,24 3.2. NMR Spectra.…”

“…The ν­(CN) band of complex 3 was shifted to a lower frequency because of the unrestrained vibration of CN outside the thiazole ring compared to the endocyclic vibration . The ν­(P–Ar) bands of complexes 1 – 3 appeared at 1431, 1431, and 1434 cm –1 , respectively, whereas the corresponding ν­(P–C) bands appeared at 1099, 1103, and 1105 cm –1 . , …”