Synthesis, Characterization and Antibacterial Activity of Cyclic Sulfamide Linked to Tetrathiafulvalene (TTF)

Bazı 3-imino-4-sübstitüe-1,2,5-tiroidyazolidin 1,1-dioksitlerin antibakteriyel etkisi

“…When the antibacterial activity of cyclic sulfamide compounds linked to tetrathiafulvalene was examined, they were found to possess tremendous or modest antimicrobial activity towards the gramnegative bacteria Escherichia coli [9]. P. aeruginosa, E. coli, and S. aureus are the most frequent pathogens responsible for and the foremost causes of nosocomial infections worldwide [2,31,32].…”

“…Notably, the structure of the five-membered -1, 2, 5-thiadiazolidine-1,1-dioxides from cyclic sulfamide derivatives could be adapted to interact with different biological receptors selectively. It is well recognized to have their essential roles as antibacterial [9], HIV protease [10], serine protease [11], antibiotics [6,12] carbonic anhydrase enzyme inhibitor [13], antiepileptic, antidiabetic, diuretic, anti-glaucoma, anticonvulsant, anti-obesity, anticancer, anti-pain, and anti-infective agents [4], agonists in serotonin receptors for Alzheimer disease [14]. From this perspective, we planned to screen the antimicrobial activity of the ISTD compounds.…”

Novel pseudonucleosides and sulfamoyl-oxazolidinone β - D -glucosamine derivative as anti-COVID-19: design, synthesis, and in silico study

“…Furthermore, the introduction of cyclosulfamide and Nsulfamoyloxazolidin-2-one into glucosamine structure can lead to interesting new chemical and pharmacological potentialities due to their biological activities with a broad application as synthetic intermediates (Bouzina et al, 2021;Nicolaou et al, 2004) especially in the asymmetric synthesis (F ecourt et al, 2010). They present a variety of interesting and useful properties that make them attractive as cyclic scaffolds for peptidomimetics in the design of protease inhibitors such as HIV protease (Hult en et al, 1999;Jadhav & Woerner, 1995;Schaal et al, 2001), serine protease (Groutas et al, 2001;He et al, 2000;Kuang et al, 2000;Yang et al, 2008), metalloprotease (Ducry et al, 1999), inhibitors of noroviruses (Dou et al, 2012), glycosidase inhibitors (Benltifa et al, 2008), and antibacterial activity (Abbaz et al, 2014;Bouzina et al, 2018).…”

Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides

“…The sulfonamide functional group stands out as one of the most important pharmacophores. At the same time, cyclic sulfonamides (sultams) have also received significant attention due to their biological activities and medicinal uses [ 1 – 7 ]. On the other hand, especially fused sultams are among the most commonly used therapeutic agents owing to the broad spectrum of their activities [ 8 – 13 ].…”