Synthesis, Characterization, and Antibacterial Activity of Lanthanide Metal Complexes with Schiff Base Ligand Produced from Reaction of 4,4-Methylene Diantipyrine with Ethylenediamine

Abstract

An environmentally friendly method for the synthesis of Schiff bases was described by combining 4,4-methylenediantipyrine with ethylenediamine. The complex was prepared in a classical way, the usual condensation reaction method. A series of metal complexes were prepared from reactions of lanthanide nitrate salts [Nd+3, La+3, Er+3, Gd+3, and Dy+3] with a Schiff base ligand. The structures of the complexes were confirmed by analytical studies, spectral measurements, and thermal studies, and the prepared ligand was characterized using microanalysis technique, UV-Visible, infrared, nuclear magnetic resonance 1H-NMR and 13C-NMR, mass spectrometry, and thermogravimetric analysis (TGA), and the addition of conductivity measurement and magnetic moment of complexes. The results showed that these complexes have a consistency of 10 in which the elements are bonded with the ligand through the two nitrogen atoms at C=N and that the bonding ratio between the metal:ligand is in 1:2 ratio. By using agar disc-spreading, we tested several in vitro compounds for their antibacterial activity against four pathogenic bacteria, including Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae. The majority of the complexes demonstrated antibacterial activity.

Synthesis, characterization, DFT studies and evaluation of the potential anti-tumour activity of nicotinic hydrazide based Schiff base using in vitro and molecular docking techniques

“…C N hyd N stretching vibrations are shown by sharp peaks around 1530 cm −1 [ 32 ]. Vibrational frequencies between 1560 cm −1 and 1417 cm −1 exhibits the presence of ν (C N) and ν (C C) bonds of the two-pyridine ring and aromatic ring respectively [ 29 , 33 ]. Also, there is a N–N bond vibrations around 1023 cm −1 .…”

Synthesis, Characterization and Biological Activity Study for Some New Metals Complexes with (3Z,3'E)-3,3'-(((2E,5E)-hexane-2,5-diylidene)bis(hydrazine-2,1-diylidene))bis(indolin-2-one)

“…Other electronic transition that occurred in ultraviolet region is n →π* electronic transition at (316 nm, 31645.569 cm -1 ). This transition causes by the presence of heteroatoms in ligand's structure such as (-N-) that contains nonbonding electrons [21]. Figure 8 Illustrates UV-Vis spectrum of Copper-L complex in diluted form at which ultraviolet transitions that referred to as π → π* and n → π* were shifted compared to the same transitions that observed in ligand's spectrum to be observed at (265 nm, 37735.849 cm -1 ) and (304 nm, 32894.736 cm -1 ) for both transitions respectively.…”

Preparation, Characterization, and Biological Activity of La(III), Nd(III), Er(III), Gd(III), and Dy(III) Complexes with Schiff Base Resulted from Reaction of 4-Antipyrinecarboxaldehyde and 2-Aminobenzothiazole

“…In a 100 mL round-bottom flask, combine 1 g (0.004624 mol) of 4-antipyrinecalreboxaldehyde and 0.6945 g (0.004623 mol) of 2-aminobenzothiazol at room temperature, adding 3-5 drops of glacial acetic acid mixed in 20 mL of pure 99.9% ethanol for 1-3 h at a stirring device [29]. After the reaction was complete, the resulting solid was crystallized by absolute ethanol once the reaction was completed.…”