Synthesis, characterization and antibacterial activity of novel heterocyclic quaternary ammonium surfactants

Jadhav, Mahantesh; Kalhapure, Rahul S.; Rambharose, Sanjeev; Mocktar, Chunderika; Govender, Thirumala

doi:10.1016/j.jiec.2016.12.013

Cited by 38 publications

(19 citation statements)

References 55 publications

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“…Most importantly, QASs have been used as disinfectants for years. The correct practice of disinfectants or their cocktail use within hospitals has long been considered the most appropriate first-line defense for decreasing the incidence of nosocomial infections and minimizing the prescription of antibiotics [ 1 , 15 , 16 , 17 , 18 , 19 ]. The ordinarily applied QASs are derivatives of benzalkonium, benzoxonium, pyridinium or cetrimonium salts [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Wide-Antimicrobial Spectrum of Picolinium Salts

et al. 2020

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Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C12, C14, C16) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C14 and C16 side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

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Section: Introductionmentioning

confidence: 99%

Wide-Antimicrobial Spectrum of Picolinium Salts

et al. 2020

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“…They are typical surfactants, composed of a hydrophilic head and a hydrophobic tail. Quaternary ammonium compounds have a wide spectrum of ability to inhibit the growth of bacteria, yeasts, molds and viruses [ 6 , 7 , 8 , 9 , 10 ]. They are the most important group of microbiocides that are used in hygienization processes.…”

Section: Introductionmentioning

confidence: 99%

Action of Monomeric/Gemini Surfactants on Free Cells and Biofilm of Asaia lannensis

2017

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We investigated the biological activity of surfactants based on quaternary ammonium compounds: gemini surfactant hexamethylene-1,6-bis-(N,N-dimethyl-N-dodecylammonium bromide) (C6), synthesized by the reaction of N,N-dimethyl-N-dodecylamine with 1,6-dibromohexane, and its monomeric analogue dodecyltrimethylammonium bromide (DTAB). The experiments were performed with bacteria Asaia lannensis, a common spoilage in the beverage industry. The minimal inhibitory concentration (MIC) values were determined using the tube standard two-fold dilution method. The growth and adhesive properties of bacterial cells were studied in different culture media, and the cell viability was evaluated using plate count method. Both of the surfactants were effective against the bacterial strain, but the MIC of gemini compound was significantly lower. Both C6 and DTAB exhibited anti-adhesive abilities. Treatment with surfactants at or below MIC value decreased the number of bacterial cells that were able to form biofilm, however, the gemini surfactant was more effective. The used surfactants were also found to be able to eradicate mature biofilms. After 4 h of treatment with C6 surfactant at concentration 10 MIC, the number of bacterial cells was reduced by 91.8%. The results of this study suggest that the antibacterial activity of the gemini compound could make it an effective microbiocide against the spoilage bacteria Asaia sp. in both planktonic and biofilm stages.

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“…It is known that the basic environment of this type of reaction accelerates the curing processes and influences the efficiency of cross-linking. In the case of a composite containing a filler, which includes montmorillonite modified with methyl dihydroxyethyl hydrogenated tallow ammonium, the effect of reducing the t 90 value could be the result of the quaternary ammonium compound acting as a surfactant [ 49 ], increasing the filler dispersion degree [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Modified Nanoclays/Straw Fillers as Functional Additives of Natural Rubber Biocomposites

2021

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Increasingly, raw materials of natural origin are used as fillers in polymer composites. Such biocomposites have satisfactory properties. To ensure above-average functional properties, modifications of biofillers with other materials are also used. The presented research work aimed to produce and characterize elastomeric materials with a straw-based filler and four different types of montmorillonite. The main research goal was to obtain improved functional parameters of vulcanizates based on natural rubber. A series of composites filled with straw and certain types of modified and unmodified nano-clays in various ratios and amounts were prepared. Then, they were subjected to a series of tests to assess the impact of the hybrids used on the final product. It has been shown that the addition of optimal amounts of biofillers can, inter alia, increase the tensile strength of the composite, improve damping properties, extend the burning time of the material and affect the course of vulcanization or cross-linking density.

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Synthesis, characterization and antibacterial activity of novel heterocyclic quaternary ammonium surfactants

Cited by 38 publications

References 55 publications

Wide-Antimicrobial Spectrum of Picolinium Salts

Wide-Antimicrobial Spectrum of Picolinium Salts

Action of Monomeric/Gemini Surfactants on Free Cells and Biofilm of Asaia lannensis

Modified Nanoclays/Straw Fillers as Functional Additives of Natural Rubber Biocomposites

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