Synthesis, Characterization and Antibacterial Activity of Some New of Novel 1,2,3-Triazole-Chalcone Derivatives from N-Acetyl-5H-Dibenzo [b,f] Azepine-5-Carboxamide

Abstract

This work involves preparation of a series of 1,2,3-triazole derivatives. In the first step, the reaction of N-acetyl-5H-dibenzo [b,f] carboxamide with different benzaldehyde derivatives to yield chalcone compounds A-D was carried out. In the second step, compounds A-D reacted with 4,4' sulfonylbis(azidobenzene) (G) to produce 1,2,3-triazole derivatives A 1 -D 1 . All the prepared compounds were characterized by Fourier-transform infrared spectroscopy (FTIR) and melting point, some of them were characterized by proton nuclear magnetic resonance ( 1 H-NMR), spectroscopy analysis. Biological activity test was done to evaluate the antibacterial activity of eight synthesized derivative compounds against two multi-drug resistant pathogenic bacteria isolated from patients infected with burn infection; Staphylococcus aureus and Pseudomonas aeruginosa. Three concentrations were selected 50, 100 and 150 mg/mL from each of the synthesized derivative compounds. The derivative compound D 1 with the concentrations of 100 and 150 mg/mL exhibited excellent effect against P. aeruginoa with inhibition zone diameters of 28.10 ± 0.5 and 28 ± 0.05 mm, respectively.

A Comparative Study of Some Parameters Levels in Infertile Women

“…Quantitative data were expressed as mean ± standard deviation. Qualitative data were given as number (n) and percentage (%) (12,13) . Correlations were determined by Spearman correlation.…”

Theoretical Study of the Geometry of Dibenzoazepine Analogues

“…Ruaa Wassim prepared a series of 1,2,3-triazole derivatives basing on N-acetyl-5H-dibenzo[b,f]azepine-5-carboxamide. One of these compounds showed an excellent activity against P. aeruginoa [11]. Kumar Honnaiah prepared a series of 5H-dibenzo[b,f]azepine derivatives to evaluate the structureantioxidant activity relationship [12,13].…”

synthesis and characterization of new imidazole azo ligand with some of transition metal ions, and their biological effect on two pathogenic bacteria of burn patients.

“…Four replicates were done for each test. The inhibition zone around each well was measured in millimetres (Adam et al, 2019) ; (Aljanaby and Alhasnawi, 2017).…”

“…Graph pad prism V.6 windows soft were was used in statically analysis to compare between diameters of inhibition zone (mm) according to T-test. P-value < 0.05 was considered indicative of statistically significant (Adam et al, 2019).…”