Synthesis, Characterization, and Antibacterial Applications of Novel Copolymeric Silver Nanocomposite Hydrogels

Abstract

Copolymeric silver nanocomposite hydrogels were synthesized by using acryloyl phenylalanine (APA), N'-isopropylacrylamide (NIPAM) and crosslinked by N,N-methylene bisacrylamide (MBA) via radical redox polymerization. Present study allows entrapping silver nanoparticles into hydrogel networks. UV-visible spectroscopy and X-ray diffraction (XRD) studies confirmed the formation of silver nanoparticles in hydrogel matrix. 11% of weight loss difference between hydrogel and silver nanocomposite hydrogel is clearly indicates the formation and silver nanoparticles by thermo-gravimetrical analysis. The order of swelling capacity values of hydrogels and silver nanocmposite hydrogels were found to be in the order of placebo copolymeric hydrogel >Ag-copolymeric silver nanocomposite hydrogels. The particle size of silver nanoparticles was analysed and are in the range of 5 -10 nm which has been confirmed by transmission electron microscopy (TEM) as well as particle size analysis. The silver nanocomposite hydrogel has shown very good antibacterial activity on gram-positive and gram-negative bacteriocides.

Antimicrobial activity of silver nanoparticles encapsulated in poly-<em>N</em>-isopropylacrylamide-based polymeric nanoparticles

“…21,22 Moreover, polymeric nanoparticles reduce concerns regarding the cytotoxicity of AgNPs because the gel limits the direct exposure of a patient's cells to AgNPs and release AgNPs slowly. 23,24 Previously, it was reported that encapsulation of AgNPs inside a polymeric nanoparticle did not affect the size and morphology of the nanocomposite.…”

“…25 Polymeric nanoparticles are an attractive vehicle for sustained AgNP release during local therapy because of their tunable size, numerous functional groups, thermo-responsiveness, high loading capacity, good stability, biocompatibility, and anionic charge. 21,24,26 In this study, we fabricated three sizes of two polymeric nanoparticle types: poly-N-isopropylacrylamide (pNIPAM) and pNIPAM-NH 2 . In each polymeric nanoparticle, we encapsulated three different concentrations of AgNPs using a water-soluble reducing agent.…”

Chitosan-poly(aminopropyl/phenylsilsesquioxane) hybrid nanocomposite membranes for antibacterial and drug delivery applications

“…More Ag nanoparticles are formed mainly around the PAPSQ particles. Several studies have reported silver nanocomposite membranes and hydrogels . According to the literature, silver nanoparticles are formed inside networks due to the anchoring capacity of the network chains.…”

pH sensitive poly(methyl methacrylate-co-acryloyl phenylalanine) nanogels and their silver nanocomposites for biomedical applications

“…fine chemicals, Mumbai, India. Acryloyl phenylalanine (APA) was synthesized as reported in earlier studies [16].…”