Synthesis, Characterization and Antibacterial Assay of Some Schiff Base Metal (II) Complexes

Uba, A.; Ladan, Misbahu Muhammad; Adamu, Usman; Magaji, Buhari; Ibrahim, Muhammad Nazifi; Sani, Mukhtar Muhammad

doi:10.9734/air/2020/v21i530204

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[11] 2-hydroxy benzaldehyde and 2-amino benzoic acid take part in the formation of Schiff base. The ligand characterized by solubility test [12] . The proposed formula of salicyladehyde and anthranilic acid of both transitional element and inner transitional element are considerably utilize in the work of co-ordination chemistry.…”

Section: Importance Of Schiff Base:-mentioning

confidence: 99%

A Review: Schiff Bases-a Versatile Pharmacophore

2022

IRJMETS

View full text Add to dashboard Cite

Formation of schiff base ligand formulated by 2-hydroxy benzaldehyde and anthranilic acid. They are solid, air and moisture stable. Many biotic activity like antibacterial, anti-inflammatory, anti tubercular, anticancer, antioxidant, antidepresent, as well as antifungal activity shown in the ligand. Schiff base ligands were correctly distinguish by melting point, solubility, conductance, measurement, water content and infrared spectroscopy. Schiff base are also known to be multitalented class of compound. Some ligang are employed as catalyst pigment and colour intermediate, organic combination polymer stabilizer. Schiff base represented by elemental analysis, IR, UV spectroscopic techniques.

show abstract

Section: Importance Of Schiff Base:-mentioning

confidence: 99%

A Review: Schiff Bases-a Versatile Pharmacophore

2022

IRJMETS

View full text Add to dashboard Cite

show abstract

“…The empirical formula determination indicated the formation of a 1:1 metal-to-ligand complexes [7] . Uba et al reported the complexation of Co(II), Mn(II) and Ni(II) with a Schiff base derived from the condensation of pentane-2,4dione and 2-aminobenzoic acid [8] . The synthesized compounds were characterized by molar conductivity, infrared spectroscopy and elemental analysis.…”

Section: Introductionmentioning

confidence: 99%

“…The molar conductance values of the complexes were small, suggestive of their non-electrolytic nature. The compounds were assayed for antibacterial activity and were found, with exception of the Ni(II) complex, to show good activity [8] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biocidal Activity of Some Schiff Base Metal(II) Complexes

Ahmed¹,

Aliyu²,

Ahmed³

et al. 2020

JJC

View full text Add to dashboard Cite

A Schiff base, 2-[4-(N,N-dimethylamino)benzylidene]benzoic acid has been synthesized by the condensation of 4-(N,N-dimethylamino)benzaldehyde and 2-amino-benzoic acid in 1:1 molar stoichiometry. The Schiff base complexes were synthesized from the chloride salts of Fe(II), Cu(II) and Zn(II) in ethanolic medium and elucidated by infrared spectroscopy, CHN elemental analysis, atomic absorption spectroscopy as well as conductivity and magnetic susceptibility measurements. The solubility and thermal stability were also determined. The metal(II) complexes are coloured solids that are soluble in DMF and DMSO. The melting point of the Schiff base was found to be 177 oC, while the complexes decompose within a temperature range of 202–261 oC suggestive of rather good thermal stability. The molar conductance values were low, indicating non-electrolytic nature of the complexes. Elemental analysis revealed that the stoichiometries of the synthesized complexes are of 1:2 metal-to-ligand ratio. All complexes were hydrated. The spectroscopic and magnetic susceptibility data revealed that the complexes possess four- coordinate distorted square planar stereochemistry, whereas the Schiff base behaves as monoanionic bidentate ligand with the nitrogen atom of the azomethine (C=N) and carboxylate oxygen (COO-) as donor sites. The Schiff base and its corresponding metal(II) complexes were assayed against a number of bacterial and fungal strains to evaluate their inhibitory potentials. All the complexes showed significant bactericidal and fungicidal activities against the tested organisms.

show abstract

Thiophene-Derived Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking

et al. 2023

View full text Add to dashboard Cite

Novel thiophene-derived Schiff base ligand DE, where DE is (E)-N 1 ,N 1 -diethyl-N 2 -(thiophen-2-ylmethylene)ethane-1,2-diamine, and the corresponding M(II) complexes, [M(DE)X 2 ] (M = Cu or Zn, X = Cl; M = Cd, X = Br), were prepared and structurally characterized. X-ray diffraction studies revealed that the geometry around the center of the M(II) complexes, [Zn(DE)Cl 2 ] and [Cd(DE)Br 2 ], could be best described as a distorted tetrahedral. In vitro antimicrobial screening of DE and its corresponding M(II) complexes, [M(DE)X 2 ], was performed. The complexes were more potent and showed higher activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, fungi Candida albicans, and protozoa Leishmania major compared to the ligand. Among the studied complexes, [Cd(DE)Br 2 ] exhibited the most promising antimicrobial activity against all the tested microbes compared to its analogs. These results were further supported by molecular docking studies. We believe that these complexes may significantly contribute to the efficient designing of metal-derived agents to treat microbial infections.

show abstract

Synthesis, Characterization and Antibacterial Assay of Some Schiff Base Metal (II) Complexes

Cited by 3 publications

References 0 publications

A Review: Schiff Bases-a Versatile Pharmacophore

A Review: Schiff Bases-a Versatile Pharmacophore

Synthesis, Characterization and Biocidal Activity of Some Schiff Base Metal(II) Complexes

Thiophene-Derived Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking

Contact Info

Product

Resources

About