Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin

Al-Tamimi, Entesar O.; Muslih, Raad M.; Thejeel, Khalida A.

doi:10.32947/ajps.v15i1.160

Cited by 3 publications

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“…Pathogenesis of CB requires molecular studies. Pasteurizing dairy milk and improving awareness may prevent Q fever-zoonosis (8) ( one of the treatments use for Q fever infection is Amoxicillin which contain 2-azetidinone compounds that acts as broad spectrum antibiotic against gm +ve and gm-ve) (9). The nomenclature classifies pregnancy losses as elective abortion (10), preembryonic loss (11), early and late fetal death (12), recurrent pregnancy loss (13), ectopic pregnancy (14), , early pregnancy loss (15), and early and late fetal death (12).…”

Section: Introductionmentioning

confidence: 99%

The incidence of coxiella infection in Iraqi women with early pregnancy loss

Alanbaki,

Baydaa Hameed Abdullah,

Wassan Abdulkarreem Abbas

et al. 2024

AJPS

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Query fever is a bacterial disease resulting from Coxiella burnetii (CB) infection in animals. It is well known that small ruminants who get Q fever lose their babies. People think pregnant women may also have lousy gestation results if they get the infection or the infection comes back to life during pregnancy. This study looks at how serologic results of Q fever and early pregnancy loss (EPL) are linked. In Baghdad, including Madinat Al-Imamain Al-Kadhmain Teaching Hospital and Abu Ghraib Hospital, multicenter case-control research was conducted from September to December 2022. A total of 90 women were enrolled in this investigation. Sixty clinically suffered from early pregnancy loss by having a nonviable intrauterine pregnancy. The other 30 women were subjects of comparable age, the week of pregnancy, and the healthy subjects as controls. Using a commercial enzyme-linked immunosorbent assay (ELISA), serum samples were screened for antibodies against CB. Three (5%) cases tested positive for CB by ELISA. The study reveals no association between adverse gestation outcomes and positive Q fever serology. Age and abortion history were not significantly correlated with C. burnetii seropositivity, according to the findings of CB cases that tested positive results.

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Section: Introductionmentioning

confidence: 99%

The incidence of coxiella infection in Iraqi women with early pregnancy loss

Alanbaki,

Baydaa Hameed Abdullah,

Wassan Abdulkarreem Abbas

et al. 2024

AJPS

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Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.

Muhsin

Alwan²,

Khan

2022

AJPS

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Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This is a new approach of incorporating, tryptophan and histidine into the the primary amino group of cephalexin, in order to provide a bulky group very close to the β-lactam ring. This chemical addition act as isosteric group to the alkoximino that protect beta lactam ring from bacterial beta lactamase enzyme. The new derivatives may show resistance to β-lactamases, improve activity and pharmacokinetic properties and may give new life for old drugs that are susceptible to hydrolysis by most β-lactamases. The chemical structures of these derivatives were confirmed by: FTIR, 1H-NMR spectroscopy, elemental micro analysis and some physical properties. Molecular docking on serine beta lactamase and prediction of ADME parameters were recorded using GOLD suite and Swiss ADME software respectively. Docking scores of the new derivatives of Cephalexin on β-lactamases were higher than those of Cephalexin, which may indicate better activity

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Synthesis A New Bis Oxazine and Thiazine Derivatives and Study Their Biological Activities

Ameen

2023

AJPS

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Oxazine and thiazine are heterocyclic organic compounds that have a wide range of pharmacological applications. In this study, some chalcone derivatives (1–5) were synthesized based on the reaction of an equal amount of p-substituted acetophenone and terephthalaldehyde in a basic medium. Oxazine derivatives (6-10) and thiazine derivatives (11–15) are synthesized from the reactions of chalcones (1-5) with urea and thiourea, respectively, in a basic medium. The newly synthesized compounds were identified using various physical techniques like 1H-NMR and FT-IR spectra, in addition to docking analysis for some of these derivatives. Finally, these compounds were tested for their biological activity, IC50, and % of PC3 cell line viability as markers of anticancer activity.

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Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin

Cited by 3 publications

References 0 publications

The incidence of coxiella infection in Iraqi women with early pregnancy loss

The incidence of coxiella infection in Iraqi women with early pregnancy loss

Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.

Synthesis A New Bis Oxazine and Thiazine Derivatives and Study Their Biological Activities

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