Synthesis, Characterization, and Antibacterial Studies of Some Metal Complexes of Dialkyl Thiourea: The X-Ray Single Crystal Structure of [CoCl₂(detu)₂]

Bis(N‐picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

“… [11] The latter contains a cobalt centre in the +1 oxidation state, however, synthetically, this metal is more commonly found in the +2 and +3 oxidation states. The first biological assays of cobalt were conducted in 1952 by Dwyer and co‐workers, [12] and over the last decade there has been a surge in interest of cobalt coordination complexes as anticancer,[ 11 , 13 , 14 , 15 , 16 ] antimalarial,[ 17 , 18 ] antibacterial[ 19 , 20 ] and antifungal agents. [ 21 , 22 , 23 , 24 , 25 , 26 ] In particular, 1,10‐bis(salicylideneamino)‐4,7‐dithiadecane cobalt(III) iodide (Figure 1 A) was screened in mice and exhibited low systemic toxicity (LD 50 =75 mg kg −1 ), bacteriostatic and bactericidal activity against Escherichia coli ( E. Coli ) and Staphylococcus haemolyticus (μM range).…”

Modern Analytical Chemistry Methods for Chalcogen Materials Analysis and Characterization

“…Most of organic and inorganic compound or ions adsorb radiation in the ultraviolet and visible region (UV-Vis) (180-750 nm). Part of chalcogen materials also produces electronic spectra that show shape of molecules or crystal as a result of the frequency absorption bands from ligands, especially for the bands near the visible region as expected [60,61]. Furthermore, the electronic transition in d-orbitals also provides strong evidence for complex compounds containing transition metals.…”

“…In this case, the X-ray penetrates through the materials, and a number of particles can be expected to be oriented in such a way as to fulfill the Bragg's law. Almost all crystalline compounds analysis rely on XRD spectra, such as analysis of metal complexes of metal-thiourea and metal phenyl-thiourea [60,61] after several steps of synthesis, to determine the coordination sphere on the metal Zn(II), Co(II) and Cu(II) and the possible crystal structures. More study of the spectra confirmed the shape of crystalline compounds together with UV-Visible and infrared as well as magnetic susceptibility measurement.…”

“…Bulk characterization by IR was employed to analyze synthetic compounds to prove the presence of thionyl vibrational mode (ν(C-S)) with frequency band shifts to lower values after coordination with metallic atoms [66]. Similar recording of infrared spectra were found in metal complexes of thiourea and phenylthiourea crystals [60,61]. The C-H stretching of the components overlapped with N-H stretching of the thiourea, but both can be differentiated since N-H is not directly involved in bond formation with the metals.…”

“…For agricultural or medicinal application, bioassay is mostly used. New materials for antimicrobial properties are tested using qualitative or quantitative microbial assay [60,61], in which pathogenic microbials were used to test the biological potentials of the compounds synthesized, as seen from disc diffusion method. The cultured microorganism in petri dishes would give clear inhibition zones around a spot of medium impregnated with stock solution of the synthesized complexes during incubation under certain conditions.…”