Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles

Synthesis, characterization and biological properties of thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes

“…Compounds having S, N and O donor atoms play a vital role in antibacterial [1][2][3] , antifungal 4,5 , antitumor 6 , antitubercular 7,8 , anticancer 9 and antiviral 10 activities due to their significant biological properties. Presently, the vanadium metal chemistry is gaining attention for its remarkable activities such as antimicrobial 11 , antitumor 12 , and most recently as insulin mimetic 13 .…”

Synthesis, Characterization and Cytotoxicity of substituted[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidines

“…[19][20][21] Among these heterocycles, the mercapto substituted 1,2,4-triazole ring systems have been well studied and so far a variety of biological activities have reported for them. 17,22,23 Recently, 4-amino-1,2,4-triazol-3-thione was used as an intermediate for the synthesis of several biologically active fused heterocyclic compounds where the amino and mercapto groups are appropriate nucleophile centers for many chemical modifications. 24 Further, many alkylated 1,2,4-triazoles linked to various aromatic ring systems either through amide or ester linkages have been reported to exhibit significant antitumor activities.…”

Synthesis of 4-aminoantipyrine derived Schiff bases and their evaluation for antibacterial, cytotoxic and free radical scavenging activity

“…Schiff bases, the easy synthesis, wide range of pharmacological activities and its azomethane functional group -CN-have tilted research in pharmaceutical and medicinal chemistry (Malladi et al, 2013). They are reported for various pharmacological activities such as bacteriostatic (Karthikeyan et al, 2006), bactericidal (Metzler et al, 1980), antimalarial (Harpstrite et al, 2008), anti-oxidant activities (Thorat et al, 2012), antiviral (Maity et al, 2012), anti-pyretic (Kalaivani et al, 2012), antifungal (Cinarli et al, 2011), insecticidal (Patil et al, 2012), anti-tumor (Venkatesan et al, 2012) and anti-inflammatory (Shivarama et al, 2003). Schiff bases synthesized from aromatic reactants have variety of applications in biological, inorganic and analytical chemistry (Kabak et al, 2000).…”