Synthesis, Characterization and Anticancer Assessment of New Nitrogen- Cyclic Compounds

Mohsein, Hanan Faleh; Jaffer, Noor Dia; Hassen, Huda Sabah; Kadhim, Athmar Ali

doi:10.21608/ejchem.2021.96112.4504

Cited by 1 publication

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“…Second, by combining the (maleic) and (phthalic) anhydrides with the (Schiff) base compound (S), the oxazepine derivatives (Z1, Z2) can be made. FT-IR, H1NMR, and 13CNMR spectroscopies were used to study all the substances [33][34][35][36]. All the produced compounds were further investigated for their physical characteristics and antibacterial activity, with promising results.…”

Section: Resultsmentioning

confidence: 99%

Preparation, investigation and studying the (physical, spectral and biological activity) of new monomers and heterocyclic compounds containing nitrogen and oxygen

Jaffer¹,

Ghafil²

2023

PEN

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This study involves the preparation of seven new compounds, some of them contain two functional groups that are considered condensation monomers. On the other hand, other compounds contain double bonds that are considered addition monomers. They started from 2-amino Thiazole with 2-hydroxy benzaldehyde (salicylaldehyde) in ethanol and hydrochloric acid to prepare azo compound (A), which reacted with acetophenone derivatives (p-bromo, p-chloro and p-hydroxy acetophenone) to prepare chalcone monomers derivatives (H1-H3). Also, the work includes preparing seven-membered heterocyclic rings through two consecutive steps; the first step includes the preparation of Schiff base compound (S). The second step includes the preparation of the oxazepine derivatives (Z1, Z2) through the cyclic closure of compound (S) with the (maleic, phthalic) anhydrides, respectively. All compounds were investigated with FT-IR, H1NMR, and 13CNMR techniques. The physical properties and the antibacterial activity were also studied for all the prepared compounds and showed good results.

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Section: Resultsmentioning

confidence: 99%