Synthesis, characterization and antimicrobial activities of mixed ligand transition metal complexes with isatin monohydrazone Schiff base ligands and heterocyclic nitrogen base

Devi, Jai; Batra, Nisha

doi:10.1016/j.saa.2014.07.041

Cited by 87 publications

(33 citation statements)

References 18 publications

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“…Antibacterial activity data shows that the metal complexes were more venomous than Schiff bases for the same strains under similar conditions. Metal complexes show more toxicity towards Gram +ve strains than Gram ‐ve strains and reason lies in the difference in the complexity of structure of the cell walls of Gram positive and Gram negative bacteria …”

Section: Resultsmentioning

confidence: 99%

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Devi

Yadav

Jindal

et al. 2019

Applied Organom Chemis

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A series of twenty compounds inclusive of bidentate Schiff bases derived from condensation of 4‐methyl‐3‐thiosemicarbazide with substituted derivatives of napthaldehyde/benzaldehyde/salicylaldehyde and their mononuclear Co (II), Ni (II), Cu (II) and Zn (II) complexes in molar ratio (1:1) were synthesized and characterized. The coordination behavior, modes of bonding and overall geometry of the compounds was known from the elemental analysis, spectral techniques (IR, UV–Vis, 1H NMR, 13C NMR, ESR and ESI‐mass), magnetic moment measurements, molar conductance, thermal and powder XRD studies. The studies revealed octahedral geometry for all the complexes where ligands coordinated in a neutral bidentate manner (NS) via nitrogen atom of azomethine group and sulphur atom of thione group with the metal centre. In vitro biological effects of the compounds were tested against four bacterial species and two fungal strains. The results indicated that the metal complexes showed a marked enhancement in biocidal activity in comparable with the parent Schiff bases. In vitro anticancer activity against the malignant tumor cell lines; human alveolar adenocarcinoma epithelial cell line (A549), human breast adenocarcinoma cell line (MCF7), human prostate cancer cell line (DU145) and human normal lung cell line (MRC‐5) using MTT assay, exposed compound 16 as a leading member with lowest IC50 value of 10.6 ± 0.14 μM against (A549) cell line.

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Section: Resultsmentioning

confidence: 99%

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Devi

Yadav

Jindal

et al. 2019

Applied Organom Chemis

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“…Synthesis and spectroscopic investigation of both chromone‐based and isatin‐based complexes have attracted particular interest as a result of the importance of these compounds and their diverse applications involving anti‐microbial, anti‐oxidant, anti‐viral, anti‐tumor, anti‐HIV and other properties …”

Section: Introductionmentioning

confidence: 99%

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

Khalil

Kishk

EL-Mekkawi

et al. 2019

Applied Organom Chemis

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A new dual‐functional Cu(II) complex and its nanohybrid form encapsulated into NaY zeolite cavities were synthesized. The synthesized compounds were characterized using elemental analyses, X‐ray fluorescence, infrared, 1H NMR, electronic, electron spin resonance and mass spectra, powder X‐ray diffraction, surface area and transmission electron microscopy in addition to conductivity and magnetic susceptibility measurements. The encapsulated Cu(II) complex was catalytically tested for degradation of industrial wastewater. The decolorization and mineralization results indicate that the Cu(II) complex encapsulated into zeolite host is an effective heterogeneous catalyst for real industrial wastewater remediation. In addition, both free and encapsulated Cu(II) complexes were tested as anti‐microbial and anti‐tumour agents. The results show that the Cu(II) complex encapsulated into zeolite has a high activity (IC50 = 14.4 μg ml−1). The results of in vivo toxicity experiments indicate that the Cu(II) complex encapsulated into zeolite is a less toxic biocompatible material (LD50 = 1245 mg kg−1). The catalytic properties, cytotoxicity and toxicity of the new nanohybrid Cu(II) complex encapsulated into zeolite make it a promising eco‐friendly and biocompatible material for water remediation and biomedical applications.

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“…Therefore, in recent years there has been a rapid expansion in research and development of novel metalbased biologically active and anticancer complexes [2][3][4]. Numerous mixed ligands transition metal complexes have been investigated by various techniques and their biological activities were extensively studied [5][6][7][8][9][10]. Chelating ligands containing O, S and N donor atoms show broad biological activity and are of special interest because of the variety of ways in which they are onded to metal ions [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

Islam¹,

Magda²

2017

Mod Chem Appl

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Four series of novel mixed ligand-drug complexes of thiamine hydrochloride as a primary ligand and four azo compounds, as secondary ligands, were prepared using Co (II), Ni (II), Cu (II) and Zr (IV) ions. The complexes were characterized by elemental analysis, thermogravimetric analysis, molar conductivity, FT-IR, magnetic susceptibility and UV-Visible spectroscopy. Based on the analytical and spectral data, the complexes were formulated as [Azo -M -Thiamine (H 2 O) n ] + Cl -where n=2 for Co (II), Ni (II) and Cu (II) and=1 for Zr (IV). All the complexes possessed octahedral geometry in which both the primary and secondary ligands act as monovalent monodentate coordinated via ON fashion in case of azo compounds and via OS fashion in case of thiamine hydrochloride. Biological activity of some complexes has been evaluated against a number of pathogenic bacteria and fungi. Obtained results indicated that the metal complexes exhibited better antimicrobial and antifungal activities.

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Synthesis, characterization and antimicrobial activities of mixed ligand transition metal complexes with isatin monohydrazone Schiff base ligands and heterocyclic nitrogen base

Cited by 87 publications

References 18 publications

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

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