Synthesis, characterization, and antimicrobial activities of novel monosaccharide-containing Schiff base ligands

Telli, Fatma Çetin; Astley, Stephen T.; Salman, Azize

doi:10.3906/kim-1606-76

Turk J Chem

2017

DOI: 10.3906/kim-1606-76

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Synthesis, characterization, and antimicrobial activities of novel monosaccharide-containing Schiff base ligands

Fatma Çetin Telli¹,

Stephen T. Astley²,

Azize Salman³

Abstract: Four new chiral Schiff base ligands (3a-4a, 3b-4b) have been prepared using aminoisopropylidene derivatives of glucose and aminochloralose derivatives of mannose. The synthesized compounds 1 and 2 were characterized by nuclear magnetic resonance (1 H and 13 C NMR), Fourier transform infrared spectroscopy (FTIR), UV/visible spectroscopy, and elemental analysis. A total of eight Schiff base compounds (3a-6a, 3b-6b) were tested for antimicrobial activity against

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Cited by 3 publications

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A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity

Kazemi,

Moini,

Rudbari

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Medicinal Research Reviews

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Chirality is a fundamental and widespread geometric structural property in living organisms that most biomacromolecules including nucleic acids, proteins and enzymes, possess. Consequently, the development of chiral drugs capable of binding specific targets have gradually gained wide attention in recent decades due to their selective effects on a broad spectrum of biological events ranging from cell metabolism to cell fate. In this context, the synthesis of chiral compounds as promising therapeutic candidates has assumed a major role in drug discovery. Among them, chiral metal complexes have attracted considerable interest due to their unique and intriguing structural features that could enable overcoming side effects and drug‐resistance phenomena of metal−based drugs currently in the market such as cisplatin. In the current scenario, an in‐depth overview of non‐platinum chiral complexes needs to be presented and carried forward. Therefore, in this perspective article, an update of the scientific development of bioactive chiral copper, zinc and nickel complexes have been reported since they have not been thoroughly reviewed so far. Specifically, we focused the article mainly on metal complexes containing chiral ligands (type 2 chirality) as in literature they are more numerous than those with chirality at the metal center (type 1 chirality). Herein, not only their biological activity but also their mechanism of action is summarized. Furthermore, in the final section of the article we have highlighted copper‐based complexes as those with a superior biological activity profile and greater prospects for development as a drug.

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A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity

Kazemi,

Moini,

Rudbari

et al. 2024

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

Synthesis, characterization and biological application of dinuclear Cu(II) complexes of Schiff base ligands of galactochloralose and α-chloralose

Salman

Barlas

Yavuz

et al. 2018

Inorganica Chimica Acta

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Chiral Schiff base ligands of salicylaldehyde: A versatile tool for medical applications and organic synthesis-A review

Jos¹,

Suja²

2023

Inorganica Chimica Acta

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Synthesis, characterization, and antimicrobial activities of novel monosaccharide-containing Schiff base ligands

Cited by 3 publications

References 34 publications

A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity

A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity

Synthesis, characterization and biological application of dinuclear Cu(II) complexes of Schiff base ligands of galactochloralose and α-chloralose

Chiral Schiff base ligands of salicylaldehyde: A versatile tool for medical applications and organic synthesis-A review

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