Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

Klaus, Jennifer; Brooks, Taylor M.; Zhou, Muyang; Veinot, Alex J.; Warman, Alexander M.; Palayew, Adam; Gormley, Patrick T.; Khuong, B. Ninh; Vogels, Christopher M.; Masuda, Jason D.; Baerlocher, Felix J.; Westcott, Stephen A.

doi:10.1007/s11243-017-0130-3

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…Some publications describe the antimicrobial properties of different 5-ASA derivatives against various bacterial strains. The lack of sensitivity of Gram-negative bacteria ( Pseudmonas aeruginosa ) and the low sensitivity of Gram-positive bacteria ( Bacillus subtilis ) to palladium Schiff base complexes derived from aminosalicylic acid were also observed by Klaus et al; however, the very poor solubility and stability of the obtained compounds excludes these compounds from the potential application as antimicrobial substances [ 26 ]. Similar conclusions were drawn from research conducted by Shehab and Rasheed [ 27 ], where it was observed that aldehyde derivatives obtained using the microwave method showed reduced antimicrobial activity against Gram-negative bacteria ( Proteus mirabilis ) and higher antimicrobial activity against Gram-positive bacteria ( Enterococcus faecalis ), at much higher effective concentrations of 5–15 mg/mL.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Bioactive Properties of the Novel Coloured Compound Obtained via the Laccase-Mediated Transformation of 5-Aminosalicylic Acid

Polak,

Grąz,

Szałapata

et al. 2024

Molecules

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Biocatalysis processes based on oxidoreductases, such as fungal laccase, are important for discovering new organic compounds with broad structures and potential applications. They include bioactive compounds, which can be obtained through laccase-mediated oxidation of organic substrates having hydroxyl and/or amino groups especially, e.g., 5-aminosalicylic acid (5-ASA) is characterised for its potential for oxidation by a fungal laccase obtained from a Cerrena unicolor strain. The biotransformation process was optimised in terms of the buffer and co-solvent concentration, buffer pH value, and laccase activity. Selected crude dyes were analysed for their bioactive properties, toxicity, and suitability for the dyeing of wool fibres. The data obtained clearly indicated that a low concentration of the reaction buffer in the pH range from 5 to 6 and in the presence of 10% acetonitrile increased the rate of substrate oxidation and the amount of the product formed. The red-brown compound obtained via laccase-mediated oxidation of 5-aminosalicylic acid showed antioxidant properties and unique antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis strains with the MIC value of 0.125 mg/mL detected for the purest dye. In addition, it was reported to have good wool fibre dyeing properties and no irritant effect after patch tests on a selected group with increased skin sensitivity.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Bioactive Properties of the Novel Coloured Compound Obtained via the Laccase-Mediated Transformation of 5-Aminosalicylic Acid

Polak,

Grąz,

Szałapata

et al. 2024

Molecules

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“…[98] A series of nine lipophilic Pd complexes with iminopyridine derivatives were synthesized and tested for antimicrobial efficiency. [99] Most of the compounds were inactive against the tested strains, mechanistic study of these compounds is needed to know abot the reason of inefficiency, so that further research line is clarified.…”

Section: Coordination Compounds For Biological Applicationsmentioning

confidence: 99%

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Khan

2021

ChemistrySelect

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Pyridine (py) is an important heterocyclic compound and is an integral part of various natural products. There are various medicines containing py ring system being available in the market to combat different human ailments. Observing the medicine market, Omeprazole, a widely used py-based drug in medicinal market since 1998. Netupitant (an antiemitic drug, since 2014) is used in combination with another drug to prevent acute and delayed vomiting and nausea associated with cancer chemotherapy led the run towards development of anticancer drugs. Several drugs have been approved by FDA for the treatment of cancer in recent years such as, Abemaciclib (2015), Lorlatinib (2018), Apalutamide (2018) and Ivosidenib (2019). Research on py on the bases of these advancements is an evergreen field and associated with greater hopes to address several disease related issues. Several compounds are in the process of clinical trials and are expected to serve various purposes in days to come. This review article deals with recent findings in py chemistry and its coordination complexes. The medicinal efficiency has been argued for organic and inorganic derivatives. Selected biological applications are hereby discussed as follow up study of our report in 2015. Suitable literature prior to 2015 has also been incorporated in appropriate places in order to cover the scope in broader sense.

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“…The activities of the prepared Schiff base ligand and its metal complexes were con rmed by calculating the activity index according to the following relation [46,47]: Activity index (A) = Inhibition Zone of compound (mm) ×100 Inhibition Zone of standard drug (mm) From the data, it was concluded that Cu(II) complex had the highest activity index, while Fe(III) complex had the lowest activity index as shown in Figure (6).…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis, Spectroscopic Properties, Anti-Breast Cancer and Anti-Microbial Studies of Some Metal Complexes for New Schiff Base Ligand Derived From Anthranilic Acid.

El‐Halim¹,

Mohamed²,

Mahmoud³

et al. 2021

Preprint

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2,2’-((1Z-1’Z) (1,3-diphenylpropane-1,3-diylidene) bis (azanylylidene)) dibenzoic acid (H2L) Schiff base ligand, was obtained by condensation reaction between anthranilic acid and dibenzoyl methane in 2:1 ratio.A series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes was resulted from 1:1 (ligand: metal salt) reaction.The structural features of the synthesized ligand and its metal complexes was determined by elemental analyses, IR, 1H NMR, UV-Vis, ESR, mass spectra, conductivity and magnetic susceptibility measurements as well as thermal (TG/DTG) analyses. The analytical and spectroscopic tools showed that the complexes had composition of ML type with octahedral geometry. The IR results confirmed the tetradendate binding of the ligand involving two azomethine nitrogen atoms and two carboxylate oxygens. The Schiff base and its complexes have been screened for their antimicrobial activity against several bacterial organisms as (Streptococcus pneumoniae and Bacillus subtilis; Pseudomonas aeruginosa and Escherichia coli) and fungi (Aspergillus fumigatus; Syncephalastrum racemosum; Geotricum candidum and Candida albicans) by disk diffusion method.All the metal complexes have potent antimicrobial activity than the free ligand. Anticancer activity of the ligand and its metal complexes was evaluated against human cancer (MCF-7 cells viability).

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Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

Cited by 11 publications

References 33 publications

Synthesis and Bioactive Properties of the Novel Coloured Compound Obtained via the Laccase-Mediated Transformation of 5-Aminosalicylic Acid

Synthesis and Bioactive Properties of the Novel Coloured Compound Obtained via the Laccase-Mediated Transformation of 5-Aminosalicylic Acid

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Synthesis, Spectroscopic Properties, Anti-Breast Cancer and Anti-Microbial Studies of Some Metal Complexes for New Schiff Base Ligand Derived From Anthranilic Acid.

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