Synthesis, Characterization and Antimicrobial Activity of Zirconium (IV) Complexes

Abstract

ABSTRACT. Heteroleptic complexes of zirconium (IV) derived from bulky Schiff base ligands containing a sulphur atom and oximes of heterocyclic β-diketones of the general formula ZrLL' (where LH 2 = , R=-C 6 H 5 , -C 6 H 4 Cl(p) and L'H 2 = , R' = -CH 2 CH 3 , -C 6 H 5 , -C 6 H 4 Cl (p) were prepared by the reactions of zirconium tetrachloride with disodium salts of Schiff bases (L Na 2 ) and oximes of heterocyclic β-diketones (L' Na 2 ) in 1:1:1 molar ratio in dry refluxing THF. The structures of these monomeric zirconium (IV) complexes were elucidated with the help of elemental analysis, molecular weight measurements, spectroscopic (IR, NMR and mass) studies. A distorted trigonal bipyramidal geometry may be suggested for these heteroleptic zirconium (IV) complexes. The ligands (bulky Schiff base ligands containing a sulphur atom and oximes of heterocyclic β-diketones) and their heteroleptic complexes of zirconium (IV) were screened against A. flavus, P. aeruginesa and E. coli.

Synthesis, Characterization, PXRD Studies, Theoretical Calculation, and Antitumor Potency Studies of a Novel N,O‐Multidentate Chelating Ligand and Its Zr(IV), V(IV), Ru(III), and Cd(II) Complexes

“…e Zr(IV) cation with its relatively small ionic radius and high positive charge number shows the characteristics of a hard Lewis acid, and it is perfect for strong complexation [47]. Zr(IV) complexes have a metalorganic framework that can be used for a variety of catalytic processes, industrial purposes, and pharmaceutical applications [44,48,49]. V(IV) complexes are reported to show various biological characteristics including antitumor, antimicrobial, antiobesity, antihyperlipidemic, and antihypertension activities, insulin-enhancing action, and improvement of oxygen-carrying efficiency of hemoglobin and myoglobin [50][51][52][53].…”