Synthesis, characterization and antimicrobial activity of mixed transition metal complexes of salicylic acid with 1, 10-phenanthroline

Lawal, Abdullahi; Shodeinde, Adeolu S.; Amolegbe, Saliu Alao; Elaigwu, Sunday E.; Yunus-Issa, Muslimat T.

doi:10.4314/jasem.v21i3.18

Cited by 5 publications

(9 citation statements)

References 7 publications

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“…The large difference between the two frequencies is greater than 200 cm -1 indicates that the carboxylate groups are coordinated to the metal ion in a monodentate fashion 35 .…”

Section: Results and Discussion: Synthesis And Characterizationmentioning

confidence: 99%

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2021

IJPSR

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“…The large difference between the two frequencies is greater than 200 cm -1 indicates that the carboxylate groups are coordinated to the metal ion in a monodentate fashion 35 .…”

Section: Results and Discussion: Synthesis And Characterizationmentioning

confidence: 99%

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2021

IJPSR

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“…The other eye‐catching phenomenon observed in this investigation is that the two newly synthesized Fe(III) complexes manifested high antibacterial activity against tested Gram‐negative and Gram‐positive bacteria compared to Fe(II) complexes reported in the literature. The Fe(II) complexes with aliphatic ligands (Mahmud et al, 2010) or mixed with aromatic heterocyclic ligands (Lawal et al, 2017) revealed no antibacterial activity against Gram‐negative ( E . coli ) and Gram‐positive ( S .…”

Section: Resultsmentioning

confidence: 99%

“…The other eye-catching phenomenon observed in this investigation is that the two newly synthesized Fe(III) complexes manifested high antibacterial activity against tested Gram-negative and Gram-positive bacteria compared to Fe(II) complexes reported in the literature. The Fe(II) complexes with aliphatic ligands (Mahmud et al, 2010) or mixed with aromatic heterocyclic ligands (Lawal et al, 2017) revealed no antibacterial activity against Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria. This shows a mixed ligand Fe(III) complexes of aromatic heterocyclic chelating ligands and acetamide would be promising combinations to develop new metalbased drugs with better antibacterial activity for both types of bacteria strains.…”

Section: S Aureus S Pyogenes E Coli K Pneumoniaementioning

confidence: 99%

“…In most of these reports, however, Co(II) complexes did not work well against Gram-negative bacteria (Shalash & Abu Ali, 2017). Likewise, literature data revealed that Fe(II) complexes with aliphatic ligands (Mahmud et al, 2010) or mixed with aromatic heterocyclic ligands (Lawal et al, 2017) demonstrated low or virtually no antibacterial activity against the tested Gram-negative and Grampositive bacteria.…”

Section: Introductionmentioning

confidence: 97%

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Synthesis, structural investigations, and in vitro biological activity of Co(II) and Fe(III) mixed ligand complexes of 1,10‐phenanthroline and 2,2′‐bipyridine

et al. 2021

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Herein, we report, four new mixed ligand complexes of Cobalt(II) and Iron(III), viz., [Co(L1)(L2)(H2O)2]Cl2 (1), [Co(L1)(L2)(L3)(H2O)]Cl2 (2), [Fe(L1)(L2)(H2O)2]Cl3 (3), and [Fe(L1)(L2)(L3)(H2O)]Cl3 (4), where L1 = 1,10‐phenanthroline (C12H8N2), L2 = 2,2′‐bipyridine (C10H8N2), and L3 = acetamide (C2H5NO)). They were synthesized and characterized using spectroscopic analysis (ESI‐MS, ICP‐OES, FT‐IR, and UV–Vis), elemental analysis, melting point determination, and conductance measurement. The in vitro antibacterial activity was tested on two Gram‐positive Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes) and two Gram‐negative Escherichia coli (E. Coli)and Klebsiella pneumoniae (K. pneumoniae) bacteria using the disc diffusion method. Based on the analytical and spectroscopic data, octahedral geometries are assigned to the complexes. Co(II) complexes were found more active against K. pneumoniae than the corresponding Fe(III) complexes which indicated that antibacterial activities of metal complexes have tuned with the nature of the metal. The results provide an insight to design and readily prepare task‐specific metal‐based drugs for interaction with particular bacterial strains.

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“…The organic salts were evaluated for in vitro antibacterial activities against strains of two Gram-positive ( S. aureus and S. pyogenes ) and two Gram-negative ( E. coli and K. pneumoniae ) bacteria. We followed the methods of Lawal et al [ 30 ]. The bacterial strains were maintained in the appropriate blood agar base at 4°C.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications

Abebe

Atlabachew

Liyew

et al. 2018

Bioinorganic Chemistry and Applications

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New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [C26H37N2]Br. Anion exchange reaction using Li[(CF3SO2)2N] resulted in a more stable salt of formula [C26H37N2][(CF3SO2)2N]. The organic salts were investigated by spectrometry (1H, 13C, 19F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI MS), CHNSBr elemental analysis, and thermal analysis (TGA and DSC). The thermal characterization showed the melting and decomposition points of [C26H37N2][(CF3SO2)2N] to be 48°C and 290°C, respectively, which indicates it is an ionic liquid with large liquidus range. The biological activities of the salts were investigated against two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria, and they are found to be active against all of them. They were compared with [Cu(1,10-phenanthroline)2Cl]Cl. They are found more active against the Gram-negative bacteria. The salts demonstrated minimum inhibitory concentration as low as 50 µg/L. These results suggest the synthesized salts can be considered as a better alternative to certain transition metal complex drugs. This minimizes the concern of introducing metal ions into the organism.

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Synthesis, characterization and antimicrobial activity of mixed transition metal complexes of salicylic acid with 1, 10-phenanthroline

Cited by 5 publications

References 7 publications

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Synthesis, structural investigations, and in vitro biological activity of Co(II) and Fe(III) mixed ligand complexes of 1,10‐phenanthroline and 2,2′‐bipyridine

Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications

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