Synthesis, Characterization and Antimicrobial Activity of New Thiadiazole Derivatives

Abstract

A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, 1 H NMR, 13C NMR and mass spectral data confirmed the structure of the newly synthesized compounds. The derivatives of these moieties were evaluated for antimicrobial activity. Most of the synthesized compounds showed good antimicrobial activity at 200 and 100 µg/mL. Compounds showed most significant antibacterial activity against gram negative test organism Escherichia coli and most significant antifungal activity against test organisms Aspergillus niger and Candida albicans. It was observed that compounds with OCH3 at 3, 4 position of phenyl ring [5(a-l)] were more potent against microbes as compared to compounds having unsubstituted phenyl ring [4(a-l)].

Synthesis and Antimicrobial Activity of Some 2-Amino-4-(7- Substituted/Unsubstituted Coumarin-3-yl)-6-(Chlorosubstitutedphenyl) Pyrimidines

“…All reagents used in the present work were of analytical grade. The 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitutedphenyl)pyrimidines (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) were prepared according to the method outlined in Scheme 1.…”

“…The antimicrobial activity of pyrimidine derivatives against broad range of microbes makes it an important skeleton in medicinal chemistry and drug development against microbes. Encouraged by these observations and also in continuation of our search for potent antimicrobial agents [9][10][11][12][13][14][15][16] including antimicrobial agents having coumarin moiety [16,17], the aim of this study was to prepare some 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitutedphenyl) pyrimidines in order to evaluate their antimicrobial activity.…”

Novel 4‐Thiazolidinones as Non‐Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA‐Dependent RNA Polymerase

“…Cyclization of chloroacetamides 15 – 21 in the presence of ethanolic solution of ammonium thiocyanate in dioxane afforded 2‐{[5‐(substituted phenyl)‐1,3,4‐thiadiazol‐2‐yl]imino}‐1,3‐thiazolidin‐4‐ones 22 – 28 . In earlier studies, 1,3‐thiazolidin‐4‐ones were obtained by the reaction of chloroacetamides with ammonium thiocyanate in ethanol or acetone , or DMF (under MW irradiation) .…”

Synthesis, Antimicrobial and Anticancer Activities of 5-(4-Substituted-Phenyl)-1,3,4- Thiadiazole-2-Amines

“…There is always a necessity to search better antimicrobial agents and the inventions of such drugs have an important role in medicinal chemistry 2 . Sulfur containing heterocyclic compounds 1,3,4-thiadiazoles are the valuable structural part of bioactive compounds 3 . 5-Phenyl-1,3,4-thiadiazole is familiar group of bioactive compounds with numerous pharmacological activities 4 .…”