Synthesis, characterization, and antimicrobial activity of new bis-1,2,3-triazol-H-yl-substituted 2-arylbenzimidazoles

Abstract

New bis-1,2,3-triazol-H-yl-substituted 2-aryl benzimidazoles VIa-VIp were synthesized from Oand N-bis-propargyl substituted 2-arylbenzimidazoles using "click chemistry." The newly synthesized compounds were characterized by IR, NMR, and mass spectra. These compounds were screened for their activity against bacterial and fungal organisms.

Recent advances in the chemistry of 2-chloroquinoline-3-carbaldehyde and related analogs

“…5 In addition, quinolines are the main core of many types of natural products, 6,7 drugs, [8][9][10] and were found in many synthetic heterocyclic compounds in order to enhance the biological and medicinal properties. Compounds incorporating quinoline ring system exhibited various biological, 11,12 and pharmaceutical activities e.g. anti-tuberculosis, 13 antiplasmodial, 14 antibacterial, 15,16 antihistamine, 17 antifungal, 18 antimalarial, 19,20 anti-HIV, 21 anticancer, 22 anti-inammatory, 23,24 anti-hypertensive, 25 and antioxidant activities.…”

Synthesis of novel isoindolone‐based medium‐sized macromolecules and triazole containing heterocyclic compounds

“…The Synthesis of 2‐(4‐((1‐phenyl‐1 H ‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)isoindoline‐1,3‐dione derivatives ( 9a‐f ) were involved in three steps. Here, 4‐amino phenol with pthalic anhydride in acetic acid at 100°C gave compound 7 , and propargylation of compound 7 afforded the corresponding 2‐(4‐(prop‐2‐yn‐1‐yloxy)phenyl)isoindoline‐1,3‐dione ( 8 ) in the presence of potassium carbonate and subsequently treated with various azides (which are generated from amines, diazotization followed by nucleophilic substitution) via 1,3‐dipolar cyclo addition (click reaction) in the presence of 10 mol% of sodium ascorbate and 10 mol% of copper sulphate afforded 2‐(4‐((1‐phenyl‐1 H ‐1,2,3‐triazol‐4‐yl)methoxy)phenyl) isoindoline‐1,3‐dione ( 9a‐f ) derivatives in excellent yields 70% to 81% as shown in scheme and physical data presented in Table .…”

Crystal structure of 3-(morpholin-4-yl)-1-phenyl-3-(pyridin-2-yl)propan-1-one

“…Morpholines are six-membered heterocycles featuring both cyclic amine and ether functional group. These compounds possess important applications in pharmaceuticals and in industries (Panneerselvam et al, 2009;Subhashini et al, 2013).…”