Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N′-di-3-propanoic acid – Crystal structure of H2-1,2-dpheddp·2HCl·H2O

Glođović, Verica V.; Ratković, Zoran; Novaković, Slađana B.; Garcı́a-Granda, Santiago; Roces, Laura; Menéndez-Taboada, Laura; Radojević, Ivana D.; Stefanović, Olgica D.; Čomić, Ljiljana R.; Trifunović, Srećko R.

doi:10.1016/j.molstruc.2012.07.007

Cited by 10 publications

(4 citation statements)

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“…Â ñâÿçè ñ ðàçâèòèåì ðåçèñòåíòíîñòè óñëîâíî-ïàòîãåííûõ áàêòåðèé è ãðèáîâ ê õèìèîïðåïàðàòàì èçûñêàíèå íèçêîòîêñè÷íûõ ñîåäèíåíèé, õàðàêòåðèçóþùèõñÿ àíòèáàêòåðèàëüíîé è ïðîòèâîãðèáêîâîé àêòèâíîñòüþ, ÿâëÿåòñÿ àêòóàëüíîé çàäà÷åé. Òàêèå ñðåäñòâà íàéäåíû, â òîì ÷èñëå ñðåäè Pt(IV) è Pd(II) êîìïëåêñîâ ýòèëåíäèàìèí-N,N¢-äèêàðáîíîâûõ êèñëîò [13,31,32].…”

Section: êîìïëåêñû Pt(iv) è Pd(ii) ñ ýòèëåíäèàìèí-Nn¢-äèêàðáîíîâûìè unclassified

“…ÝÄÄbÏ (ìåçî-1,2-äèôåíèëýòèëåíäèàìèí-N,N¢-äè-3-ïðîïèîíîâîé êèñëîòû) (VIII) õàðàêòåðèçóåòñÿ ìîùíîé àêòèâíîñòüþ, èíãèáèðóþùåé áàêòåðèàëüíûé ðîñò, òîãäà êàê åãî ôóíãèöèäíîå äåéñòâèå, õîòÿ è îòìå÷åíî, íî âûäàþùèõñÿ ðåçóëüòàòîâ íå ïîêàçàëî. Ïîäîáíîå, íî ìåíåå âûðàaeåííîå àíòèáàêòåðèàëüíîå äåéñòâèå ïðîÿâèë Pt(IV) êîìïëåêñ, àíàëîãè÷íûé êîìïëåêñó VIII [13].…”

Section: êîìïëåêñû Pt(iv) è Pd(ii) ñ ýòèëåíäèàìèí-Nn¢-äèêàðáîíîâûìè unclassified

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Комплексы Металлов С Этилендиаминдикарбоновыми Кислотами И Их Производными — Перспективные Фармакологические И Диагностические Агенты (Обзор)

Tsirul'nikova¹,

Podmareva²

2014

Хим.-фарм. ж.

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Обобщены сведения по рассмотрению комплексов металлов с этилендиаминдикарбоновыми кислотами и их производными в качестве перспективных фармакологических и диагностических препаратов. Комплексы металлов платиновой группы являются перспективными противораковыми веществами. Для некоторых комплексов Pt(IV) и Pd(II) выявлены бактерицидные и фунгицидные свойства. Комплексы Zn(II) и Vo(IV) с этилендиамин-N,N’-дикарбоновыми кислотами рассматриваются в качестве гипогликемических (инсулиномиметических) средств. Комплексы металлов-нуклидов (99mTc, 111In, 67Ga) описаны в качестве диагностических радиофармацевтических препаратов.

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Section: êîìïëåêñû Pt(iv) è Pd(ii) ñ ýòèëåíäèàìèí-Nn¢-äèêàðáîíîâûìè unclassified

Комплексы Металлов С Этилендиаминдикарбоновыми Кислотами И Их Производными — Перспективные Фармакологические И Диагностические Агенты (Обзор)

Tsirul'nikova¹,

Podmareva²

2014

Хим.-фарм. ж.

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“…The preparation and spectral characterization of meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid and corresponding platinum(IV) and palladium(II) complexes were published earlier [8] using the same method as Liu [9]. In the present study, palladium(II) complex with meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid was characterized by X-ray analysis.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid. Crystal structure of [Pd(1,2-dpheddp)] complex

Mijajlović

Nikolić

Jevtić

et al. 2016

Maced. J. Chem. Chem. Eng.

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The syntheses of tetradentate ligand, meso-1, 2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid (H 2 -1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and B16F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 μM of platinum(IV) complex in the B16F1 cell line.Keywords: meso-1, platinum(IV) complex; palladium(II) complex; crystal structure; cytotoxicity ЦИТОТОКСИЧНОСТ НА КОМПЛЕКСИТЕ НА ПЛАТИНА(IV) И ПАЛАДИУМ(II) СО meso-1,2-ДИФЕНИЛ-ЕТИЛЕНДИАМИН-N,N'-ДИ-3-ПРОПАНОНСКА КИСЕЛИНА. КРИСТАЛНА СТРУКТУРА НА КОМПЛЕКСОТ НА [Pd(1,2-dpheddp)]Во овој труд е опишана синтезата на тетрадентатниот лиганд, meso-1,2-дифенил-етилендиамин-N,N'-ди-3-пропанонска киселина (H 2 -1,2-dpheddp), со соодветните комплекси на платина(IV) и паладиум(II). Спектроскопски предвидената структура на добиениот комплекс на паладиум(II) е потврдена со рендгенска структурна анализа. Монокристалите соодветни за рендгенските испитувања се добиени со бавна кристализација од воден раствор на DMSO. Цитотоксичните ефекти на комплексите на платина(IV) и на паладиум(II) врз типови на клетки 4T1 и B16F1 се определени со MTT колориметрија и споредени со соодветните ефекти на цисплатин. Двата комплекса покажаа дозирачки зависен цитотоксичен ефект врз двата типа клетки. Двата комплекса покажаа послаба активност од онаа на цисплатин, со исклучок на повисоките концентрации (над 62,5 μM) на комплексот на платина(IV) спрема клетките B16F1.Клучни зборови: meso-1, 2-дифенил-етилендиамин-N,N'-ди-3-пропанонска киселина; платина(IV)-комплекс; паладиум(II)-комплекс; кристална структура; цитотоксичност M. Ž. Mijajlović et al.

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“…Morbidity and mortality caused due to bacterial and fungal infections are the major cause of health problems in developing countries [ 1 ] . Propanoic acid derivatives are reported to have a diverse spectrum of biological activities including antimicrobial activity [ 2 ] . QSAR analysis applies statistical methods to describe relationship between chemical structure and biological activities of a series of analogs quantitatively [ 3 ] .…”

mentioning

confidence: 99%

Synthesis, Antimicrobial Evaluation and QSAR Studies of 2-hydroxy Propanoic Acid Derivatives

2013

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A series of 2-hydroxypropanoic acid derivatives (1-26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMICam values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier's valance second order molecular connectivity index (2χv) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives.

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Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N′-di-3-propanoic acid – Crystal structure of H2-1,2-dpheddp·2HCl·H2O

Cited by 10 publications

References 49 publications

Комплексы Металлов С Этилендиаминдикарбоновыми Кислотами И Их Производными — Перспективные Фармакологические И Диагностические Агенты (Обзор)

Комплексы Металлов С Этилендиаминдикарбоновыми Кислотами И Их Производными — Перспективные Фармакологические И Диагностические Агенты (Обзор)

Cytotoxicity of platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid. Crystal structure of [Pd(1,2-dpheddp)] complex

Synthesis, Antimicrobial Evaluation and QSAR Studies of 2-hydroxy Propanoic Acid Derivatives

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