Synthesis, Characterization and Antimicrobial Evaluation of Some Novel Chromenopyridine, Pyranochromene and 3-Hetarylcoumarin Derivatives

Mohamed, Khaled S.; Elbialy, Engy E.

doi:10.3987/com-20-14264

Cited by 2 publications

(1 citation statement)

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“…Functionalized chromenes are widely used to synthesize promising compounds in medicinal chemistry [28][29][30][31][32][33][34][35] . Wide-ranging pharmacological activity, such as antibacterial 36 , anti-inflammatory 37 , antimicrobial 38 , anti-proliferative 39 , hypotensive 40 , and antirheumatic 41 properties, have been reported for derivatives of chromenopyridine. Many natural and pharmaceutical compounds contain fused chromenes like chromenopyridines.…”

Section: Introductionmentioning

confidence: 99%

Bis(2-cyanoacetamide) in Heterocyclic Synthesis: Synthesis of Some Bis[2-oxopyridine, 2-iminochromene, Chromeno[3,4-c]pyridine, Benzochromeno[3,4-c]pyridine] Derivatives

Thabet,

Imran,

Imran

et al. 2024

Orient. J. Chem

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N,N'-(methylenebis(1,4-phenylene))bis-(2-cyanoacetamide) was exploited as a precursor for synthesing some bis (benzylidene 5a-c, pyridines 7, 8, 10a,b, chromene 14, benzochromene 15) derivatives containing diphenyl-methylene spacer via the reaction with each of aromatic aldehydes, pentane-2,4-dione, acetaldehyde/ malononitrile, arylidene-malononitriles, ethyl cinnamates, 2-hydroxybenzaldehyde, and 2-hydroxy-1-naphthaldehyde). Bis(chromeno[3,4-c]pyridines 16&18) were synthesized via Michael's addition of malononitrile or ethyl cyanoacetate to bis(chromene) derivative. The newly prepared compound structures were established via ir, NMR spectroscopic data.

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