Synthesis, Characterization and Antimicrobial Evaluation of New Azo Compounds Derived from Sulfonamides and Isatin Schiff Base

Abstract

The present study deals with the synthesis of four different azo-azomethine derivatives; this is done by two steps; the first step is diazotization of sulfonamides (sulfanilamide, sulfacetamide, sulfamethoxazole, and sulfadiazine) separately, followed by the second step; the coupling reaction of diazotized compounds with isatin bis-Schiff base named 3-((4-nitrobenzylidene) hydrazono)indolin-2-one. The later one (bis-Schiff base) was synthesized by the reaction of 3-hydrazono-indolin-2-one with p-nitrobenzaldehyde. The chemical structures of newly synthesized compounds were approved on the basis of their FTIR, 1H-NMR, and CHNS elemental analysis data results. The synthesized azo compounds were tested in vitro for their antimicrobial potential using well diffusion method. All the target compounds were clearly inhibited Escherichia coli and Candida albicans, while only compounds 2b and 2c show antibacterial activity against Pseudomonas aeruginosa. The most active compound among the prepared azo compounds against Escherichia coli, Pseudomonas aeruginosa, and Candida albicans is compound 2b.

Synthesis, Characterization of New Metal Complexes of Co (II), Cu (II), Cd (II) and Ru (III) from azo ligand 5-((2-(1H-indol-2-yl)ethyl) diazinyl)-2- aminophenol, Thermal and Antioxidant Studies

“…The pattern of fragmentation is summarized in Scheme3. The molecular ion peak, which corresponds to the ligand formula weight, has peaked at m/z=355.42 and shows many peaks at(m/z) (337.24,207.08,130.17,103.10 and 91.96).The pattern for these peaks may be assigned to various fragments with C16H14N4CoO + ,C7H6CoN3O + ,C9H8N + ,C6H3N2 + and H3CoNO + ) respectively [11][12][13][14] .…”

Synthesis, Characterization, Biological Activity, and Molecular Docking Study of Some New Sulfamethoxazole Derivatives.

“…Whatman (no.3), filter paper discs (mm), were impregnated with 20 ml of each of the prepared diluted solvents, and the discs were stored at room temperature. Muller Hinton agar was covered with discs containing both natural and synthetic ingredients 19,20…”

Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors

“…Isatin is a member of the indoles' compounds and an interesting endogenous biologically active molecule. It could undergo chemical modification to produce many organic compounds with various biological activities, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant (Al-Mudhafar and Kamoon 2020;Al-Wabli et al 2020;Ismail et al 2022).…”