Synthesis, characterization, and antimicrobial evaluation of new pyrazolines incorporating imine moiety

Abstract

A novel series of pyrazoline derivatives (3-9) was synthesized and identified by using several spectral analysis. Chalcone compound (1) was prepared as a starting material from the reaction of 4-aminoacetophenone and furan-2-carboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Cyclization reaction of 1 by the action of hydrazine hydride afforded compound 2: 4-(5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-3-yl) aniline. The target compounds (3-9) were obtained from the reaction of 2 with corresponding aldehydes in ethanol. The synthesized compounds were in vitro screened against several bacterial strains: Staphylococcus aureus, Staphylococcus espidermididis, Escherichia coli, Klebsiella sp, as well as, Candida albicans. These compounds exhibit a moderate to good activity.

Synthesis of Pyrazoline Derivatives and Their Pharmacological Activities: A Review of the Last Decade

“…In the next step, the chalcone derivative reacted with hydrazine hydrate in an ethanol medium under reflux conditions to give the desired product in good yield. [49] (Scheme 26)…”

“…In this method, 4‐amino acetophenone reacted with furan 2‐carboxyaldehyde in the presence of a base in an ethanol medium to give a chalcones derivative. In the next step, the chalcone derivative reacted with hydrazine hydrate in an ethanol medium under reflux conditions to give the desired product in good yield [49] . (Scheme 26)…”