Synthesis, characterization and antimicrobial properties of a Co(II)-phthalylsulfathiazolate complex

Abstract

The reaction between phthalylsulfathiazole (H(2)PST), in alkaline aqueous solution, and cobalt(II) nitrate led to a pink solid, [Co(PST)(H(2)O)(4)] (1), which was characterized by elemental and thermogravimetric analysis; FT-IR, Raman and diffuse reflectance spectra. Spectroscopic data reveal that the ligand would be doubly deprotonated and that the Co(II) ion environment is a distorted octahedral one. (1) showed antibacterial activity similar to the ligand.

Heteroleptic complexes of antifungal drugs with the silver ion

“…Both MIC and MFC were confirmed by two replicates. Despite the specialized international recommendations, a variety of breakpoints is observed in the literature, so we decided to take the value of 250 µg/mL as cut‐off point for MIC's 21e,f,35 against all the analyzed fungi.…”

Antifungal, phyto, cyto, genotoxic and lipophilic properties of three complexes of sulfadimethoxine (HSDM) with Ag(I). Synthesis and characterization of [Ag3SDM(SCN)2]·H2O and [Ag2(SDM)2o-phenanthroline]·H2O

“…Both MIC and MFC were confirmed by two replicates. Despite the specialized international recommendations [15] a variety of breakpoints is observed in the literature [16], so we decided to take the value of 250 μg/mL as cut-off point for MICs [11,12,17] against all the analyzed fungi: MICs ≤ 250 µg.mL -1 were considered active. Amphotericin B (Janssen Pharmaceutica, Beerse, Belgium), Ketoconazole (Sigma-Aldrich, St Louis, MO, USA) and Terbinafine (Novartis, Bs.…”