Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

Abstract

In an effort to find a new pharmacologically dynamic molecule, we report here the synthesis and in vitro antimicrobial activity of various N-(4-methyl-5-(4-((substituted phenylamino) methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl) benzamides. The structures of newly synthesized compounds were assigned on the bases of IR, 1 H NMR, 13 C NMR, and mass spectral data. Synthesized compounds were screened for their antibacterial and antifungal activities on gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gramnegative bacteria (Escherichia coli and Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial broth dilution method. Compounds 5e and 5k were associated with considerable potential antibacterial and compounds 5a and 5b antifungal activities.

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

“…Moreover, 2-pyridones are a class of newly exposed potent antibacterial agents that are of specific concern due to their in vitro and in vivo antibacterial potencies against the bacterial type II DNA topoisomerases, which consist of two highly homologous enzymes-DNA gyrase and topoisomerase IV [22,23]. In accordance with our previous work [24,25,26] and medicinal importance of coumarin and 2-pyridone motifs we report herein the synthesis of a new class of 6-((arylidene)amino)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o as potential antimicrobial agents.…”

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

“…Moreover, 2-pyridones are a class of newly exposed potent antibacterial agents that are of specific concern due to their in vitro and in vivo antibacterial potencies against the bacterial type II DNA topoisomerases, which consist of two highly homologous enzymes-DNA gyrase and topoisomerase IV [22,23]. In accordance with our previous work [24,25,26] Online: 2016-05-30…”

A Review on the Preparation of 1,3,4-Oxadiazoles From the Dehydration of Hydrazines and Study of Their Biological Roles

“…Desai et al [39] in 2015 prepared the thiazole based 1,3,4-oxadiazole derivatives. Synthetic route for the preparation of these compounds is shown Scheme 7.…”