Synthesis, Characterization and Antimicrobial Studies of 1-(5-Bromo-2-Hydroxyphenyl)-3-(4- Bromophenyl)-Propane-1,3-Dione and Their Transition Metal Complexes

Abstract

A new ligand 1-(5-bromo-2-hydroxyphenyl)-3-(4-bromophenyl)-propane-1, 3-dione have been synthesized from 5bromo-2-hydroxyacetophenone and 4-bromo benzoic acid. Their transition metal complexes have been synthesized. 1, 3-dione or ligand co-ordinate with the transition metal ions through oxygen atoms. The stiochimetry ratio ligand to metal has been 2:1. The synthesized 1,3-dione and their transition metal complexes have been characterized by 1 H-NMR, 13 C-NMR,IR, Elemental analysis, Powder XRD, TGA. Solution conductivity, Magnetic susceptibility and Antimicrobial screenings were also studied using Resazurin 96 well plate method. Tetracycline and Amphotericin B are used as standard drugs. The transition metal complexes showed moderate to excellent antimicrobial activity against all tested bacteria and fungi.