Synthesis, Characterization and Antimicrobial Studies of Triazole - Thiazolidine Clubbed Heterocyclic Compounds

Abstract

4-Amino-1,2,4-traizol (I) on condensation with 5-Phenyl substituted-2-furan carboxaldehyde (IIa-e) yield schiff bases namely N-[(5-Arylfuran-2-yl)methylen]-4H-1,2,4-triazol-4-amine (IIIa-e). Each of schiff base on cyclization with Thioglycolic acid afforded 2-(5-Arylfuran-2-yl)-3-(4H-1,2,4-triazol-4-yl) thiazolidin-4-one (IVa-e). Following this mannich base reaction of each IVa-e with Formaldehyde and Piperidine give 2-(5-Arylfuran-2-yl)-5-(piperidin-1-yl methyl)-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (Va-e). All the compounds of each series were characterized by spectral features and elemental contents. The compounds were also screened for their antimicrobial behavior.