Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin

Abstract

Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1 H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.

Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one

“…This fused bicyclic compound was earlier known as benzo-1,3-diazine [ 15 ]. Imines (Schiff bases) and their reaction products are an important class of the most widely used organic compounds and have been studied over the years and reported to possess a wide range of biological activities such as anti-inflammatory [ 16 ], anticonvulsant [ 17 ], antimicrobial [ 18 ], antioxidant [ 19 ], cytotoxic [ 20 ], and antitubercular [ 21 ].…”