Synthesis, characterization and antitumor activity of novel tetrapodal 1,4-dihydropyridines: p53 induction, cell cycle arrest and low damage effect on normal cells induced by genotoxic factor H₂O₂

Abstract

Synthesis of novel tetrakis(2,6-dimethyl-4-phenyl-1,4-dihydropyridinyl)methanes5a–dby acid-catalyzed condensation of the tetrakis-aldehydes6a–dwith eight equivalents of 3-aminobut-2-enenitrile2is reported. Antitumor activities of compounds5a–dwere also investigated.

Synthesis, Docking Simulation, Biological Evaluations and 3D-QSAR Study of 1,4-Dihydropyridines as Calcium Channel Blockers

“…Various modulators can potentiate or block calcium entry through L-type calcium channels. [4][5][6] Calcium antagonists have a versatile pharmacological activity such as antihypertensive and antianginal, [7][8][9] antitumor, 10,11) anti-inflammatory, 12,13) antitubercular, 14,15) anticonvulsant and antithrombotic. 16,17) 1,4-DHPs bind selectively to L-type calcium channel protein, precisely at the transmembrane domain IIIS6 and IVS6 regions of the α1 subunit.…”

Green synthesis of polyhydroquinolines via MCR using Fe3O4/SiO2-OSO3H nanostructure catalyst and prediction of their pharmacological and biological activities by PASS

“…The isolated yields were 97, 95, 94, 92, 91 and 90% for the fresh catalyst and five subsequent recycled runs, respectively. As a result, the catalytic performance and recyclability of Fe 3 O 4 /SiO 2 -OSO 3 H were better than catalysts previously reported in the literature [8][9][10][11][12] and also our earlier works [13,20].…”

“…Therefore, several synthetic methods have been reported in the literature for their synthesis [8][9][10][11][12][13]. Although these various methods have some advantages for the synthesis of polyhydroquinolines, they have some drawbacks such as harsh reaction conditions, use of expensive catalysts or reagents, tedious workup procedures, sensitivity to water and toxicity.…”

Bis(enaminones) as Versatile Precursors for Novel Bis([1,2,4]triazolo[1,5‐a]pyrimidines) and Bis(2‐thioxo‐2,3‐dihydropyrido[2,3‐d]pyrimidin‐4(1H)‐ones)

“…In the last decades, our group has been heavily involved in a program aiming at exploring the synthetic potentiality of functionally substituted enamines . In continuation to this work, and in conjunction to our interest in the chemistry of bis(heterocycles) , we report herein on the reactivity patterns of enamines towards 1 H ‐1,2,4‐triazol‐5‐amine and 6‐amino‐2‐thioxopyrimidin‐4‐one.…”