Synthesis, characterization and aqueous dispersion of dextran-g-poly(1,4-dioxan-2-one) copolymers

Bajgai, Madhab Prasad; Parajuli, Daman Chandra; Ko, Ji Hyun; Kang, Hyo Kyoung; Khil, Myung-Seob; Kim, Hee Young

doi:10.1016/j.carbpol.2009.07.009

Cited by 20 publications

(4 citation statements)

References 30 publications

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“…Selain PCL, gugus hidrofobik lain seperti poly (acrylic acid), phosphorylcholine, carboxymethyl chitosan, dextran, polyethylenimine (PEI), poly-L-lysine (PLL), dan polyallylamine (PAA) telah digunakan dalam riset pengembangan obat sebagai tulang punggung polimer. [12][13][14][15][16][17][18][19] Pemilihan gugus hidrofobik dilakukan berdasarkan kemudahan fabrikasi, stabilitas, dan biaya keseluruhan bahan. Gugus hidrofobik yang umumnya diteliti untuk sintesis kopolimer cangkok (graft) adalah PCL, PLA, PLGA, alkil rantai panjang kolesterol, dan PEO.…”

Section: Pemilihan Karakteristik Polimerunclassified

Sistem Penghantaran Obat Dengan Misel Polimer

Milala

2022

MEDICINUS

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Saat ini dapat dikatakan sebagai era nanoteknologi, karena teknologi ini digunakan hampir di segala bidang, termasuk bidang tekonologi farmasi yang mulai gencar mengembangkan sediaan farmasi dengan dengan sistem nano. Salah satu sistem nano tersebut berupa misel polimer, yang umumnya memiliki ukuran partikel di bawah 100 nm. Berdasarkan hasil riset, misel polimer terbukti mampu meningkatkan kelarutan serta bioavailabilitas obat yang bersifat hidrofobik. Terdapat beberapa metode pembuatan misel polimer yang masing-masing memiliki keunggulan dan kekurangan. Evaluasi yang dilakukan untuk mengkarakterisasi misel polimer di antaranya adalah penentuan critical micelle concentration (CMC), ukuran partikel, karakteristik permukaan, stabilitas, dan uji pelepasan. Walaupun sebagian besar riset misel polimer diaplikasikan dalam bidang onkologi dengan rute pemberian intravena, namun saat ini semakin banyak peneliti yang mengembangkan riset pengembangan obat untuk rute pemberian per oral. Dengan semakin banyak riset terkait penerapan teknologi misel polimer untuk obat per oral, diharapkan dapat mendorong uji klinik seperti yang dilakukan pada obat-obatan intravena.

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Section: Pemilihan Karakteristik Polimerunclassified

Sistem Penghantaran Obat Dengan Misel Polimer

Milala

2022

MEDICINUS

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“…Poly( p -dioxanone) (PPDO) as a semicrystalline aliphatic polyester with excellent biocompatibility and biodegradability properties has received increasing attention in the biomedicine-related fields. − Unlike the well-known aliphatic polyesters such as PCL and PLLA, little information about living CDSA of PPDO core-forming BCPs has been reported. Up to now, Wang and co-workers have reported the self-assembly of PPDO- b -PEG (PEG = poly(ethylene glycol)) BCPs in aqueous solution using a heating–cooling process. − They revealed that PPDO- b -PEG composed of a 3-arm star-like structure would form the “star anise”-like micelles in aqueous solution through the “crystallization-induced hierarchical assembly” mechanism. , However, the living CDSA behavior of PPDO core-forming BCPs in selective solvents still remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Precise Control of Two-Dimensional Platelet Micelles from Biodegradable Poly(p-dioxanone) Block Copolymers by Crystallization-Driven Self-Assembly

et al. 2022

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Two-dimensional (2D) core–shell nanoparticles have been attracting increasing interest due to their wide applications in materials science. Living crystallization-driven self-assembly (CDSA) is an ambient temperature, seeded growth method of crystallizable block copolymers (BCPs) in selective solvents, which has been demonstrated to be a powerful tool for the creation of one-dimensional (1D)/2D nanomaterials with precise control over size and compositions. Nevertheless, the development of an efficient living CDSA approach is a challenge for the case of semicrystalline poly(p-dioxanone) (PPDO) as a core-forming block, where the dimensional control is poor. Herein, we demonstrate that the insufficient size control of 2D PPDO platelets could be overcome through modulation of solvent compositions or elevating the crystallization temperatures for PPDO. The possible mechanism involves an improved unimer solubility that avoids fast unimer aggregation. As a result, uniform 2D platelet micelles with a controlled area over a substantial size range are created via epitaxial growth of the unimer. It is noteworthy that the shape control of 2D platelet micelles from quasi-square to elongated hexagon to lozenge shapes can be accessible by regulating the crystallization conditions such as adding different amounts of cosolvents or crystallization at an elevated temperature. Meanwhile, spatially defined block comicelles can be achieved via the seeded growth approach from PPDO core-forming BCPs with different corona functionalities at elevated temperatures. The excellent water stability and biocompatibility properties of 2D PPDO platelet micelles further enable them to have a potential application as cargo vehicles in the drug delivery field.

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“…On the other hand, the grafting of hydrophobic type monomers, for example, aliphatic meth(acrylate)s or aromatic vinyl monomers, for example, styrene with polysaccharide backbone allows the synthesis of amphiphilic materials, which can be successfully utilized as a fillers, stabilizers, modifiers, matrices as well as more environmentally friendly polymers than synthetic plastics in many practical applications [15][16][17][18][19][20][21]. There are number of papers that describe the influence of different reaction parameters and different experimental methods on the course of the grafting process of vinyl monomers with carbohydrate polymers [11,19,[22][23][24][25][26][27][28][29][30]. However, according to literature survey, little information on the grafting reactions of aromatic meth(acrylate)s onto polysaccharide backbone is available.…”

Section: Introductionmentioning

confidence: 99%

Starch‐g‐poly(phenyl acrylate) copolymers—synthesis, characterization, and physicochemical properties

Worzakowska

2017

Starch Stärke

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Synthesis, characterization, and physicochemical properties of some novel starch‐g‐poly(phenyl acrylate) copolymers are presented. The chemical modification of gelatinized potato starch by grafting with phenyl acrylate using K2S2O8 as a radical initiator and employing different reaction conditions was studied in detail. Depending on the reaction conditions, the grafting parameters were changed, achieving their maximum values (grafting percent G: 41.8%, grafting efficiency GE: 82.3%) at 80°C under a reaction time of 150 min and starch to monomer ratio of 1:2. Spectroscopic methods (FTIR and 13C CP/MAS NMR) confirmed the successful formation of copolymers under the radical reaction of primary and secondary OH groups of starch and carbon–carbon double bonds of phenyl acrylate monomer. Scanning electron microscopy (SEM) indicated a non‐porous, rough, and heterogeneous structure of the copolymers. The blocking of some hydroxyl groups of starch by phenyl acrylate chains allowed more moisture resistant and more acid resistant copolymers to be compared, as compared to unmodified starch. Moreover, the copolymers were insoluble in polar and non‐polar solvents; however, they were able to undergo swelling. The range of swelling was dependent on the grafting parameters as well as the polarity of the solvents. According to DSC analysis, the copolymers exhibited a glass transition temperature of ca. 63–65°C and decomposed under two steps, which were directly connected with the degradation of starch and phenyl acrylate chains.

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Synthesis, characterization and aqueous dispersion of dextran-g-poly(1,4-dioxan-2-one) copolymers

Cited by 20 publications

References 30 publications

Sistem Penghantaran Obat Dengan Misel Polimer

Sistem Penghantaran Obat Dengan Misel Polimer

Precise Control of Two-Dimensional Platelet Micelles from Biodegradable Poly(p-dioxanone) Block Copolymers by Crystallization-Driven Self-Assembly

Starch‐g‐poly(phenyl acrylate) copolymers—synthesis, characterization, and physicochemical properties

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