Synthesis, Characterization, and Bacterial Activity of Co(II), Ni(II), and Pd(II) Complexes with Ligands of Thymine, Uracil Thiuram Disulfur, and Cyclic Amines

Mohammed, Modher Y.; Karim, Mohamed G. Abdel; Karim, Hind M. Abdul

doi:10.1002/masy.202100310

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Antibacterial for complexes tested toward Gram positive (+) bacteria, Staphylococcus aureus and Gram negative (-) bacteria, Klebsiella pneumonia using the agar diffusion procedure and inoculation plate 15,16 . The tested complexes for antibacterial activity were dissolved in dimethyl sulfoxide at 30.0 µg/disc.…”

Section: Antibacterial Activitymentioning

confidence: 99%

املاح الفلزات الانتقالية الأولى للدايازونيوم المشتق من مركب حلقي غير متجانس للنيتروجين تحضيرو تشخيص و الفعالية الحيوية

Mohammed,

Alyass

2024

Baghdad Sci.J

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Metal complexes chrome(III), manganese(II), iron(III), cobalt(II), nickel(II), cupper(II) and zinc(II) with diazonium of 3-amino-2-chloropyridine of general formula [2-Cl-C5H3N≡N]n[MXm], where n=2 or 3 for divalent and trivalent metal, m= 4 or 6 were synthesized. The complexes have been characterized by flame atomic absorption, (C.H.N), molar conductance, magnetic susceptibility UV-vis spectra, infrared spectra,1H-NMR spectroscopy and thermo gravimetric analysis (TGA and DTA). The measurements showed that the divalent metal ion complexes (M2+) have (1:2) M:L ratio with tetrahedral geometry around metal ions while the trivalent metal ions (M3+) formed (1:3) metal: ligand ratios with octahedral geometry. Furthermore, the complex salts were displayed for antibacterial activity versus two types of bacteria Gram, positive (Staphylococcus aureus) and Gram negative (Klebsiella pneumonia). The complex 2 Mn(II) and 3 Fe(III), exhibited moderate activity against the two tested bacteria, while the complexes 1 Cr(III), 4 Co(II) 6 Cu(II) and 7 Zn(II) showed high activity .The complex 5 Ni(II) displayed moderate and weak against the type one and type two of bacteria respectively.

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Section: Antibacterial Activitymentioning

confidence: 99%

املاح الفلزات الانتقالية الأولى للدايازونيوم المشتق من مركب حلقي غير متجانس للنيتروجين تحضيرو تشخيص و الفعالية الحيوية

Mohammed,

Alyass

2024

Baghdad Sci.J

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“…The uracil-metal complexes can have square planar and octahedral geometries [3,4]. Uracil's substituted in position five stand out in bioactivity, with various biological activities including antiviral properties, anticancer, cytotoxic, anti-mycobacterial, and antitumor, to antibacterial [14][15][16][17][18][19][20][21][22][23]. In this manuscript we aim to synthesize new Mg(II), Ca(II), Sr(II) and Ba(II) complexes of uracil and report an assessment of their coordination behavior using spectral measurements and thermal studies.…”

Section: Introductionmentioning

confidence: 99%

Complexation of some alkaline earth metals with bidentate uracil ligand: Synthesis, spectroscopic and antimicrobial analysis

A.O. Younes,

S. Refat,

A. Saad

et al. 2023

Bull. Chem. Soc. Eth.

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ABSTRACT. Magnesium, calcium, strontium, and barium complexes of uracil were prepared in a 2:1 ligand to metal ratio to investigate the ligational character of the uracil (Ura). The modes of chelation were explained depending on elemental analyses, FT. IR, 1H–NMR spectra as well as scanning electron microscopy. Uracil has two donation sites either through N(3) and C(2)=O, or through N(3) and C(4)=O with the molecular formulas [M(Ura)2(H2O)2]Cl2 where M = Mg(II), Ca(II), Sr(II) and Ba(II) . The morphological surface and particle size of uracil metal complexes were determined using SEM and TEM. The thermal behaviors of the complexes were studied by the TGA (DTG) technique. The data obtained agreed well the proposed structures and showed that the complexes were finally decomposed to the corresponding metal oxide. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz–Metzger methods. The negative values of deduced the ordered structures of the prepared complexes compared to their starting reactants. Antibacterial activity of ligands and complexes is evaluated with two types of bacteria Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) by the agar-well diffusion technique using DMSO as a solvent. KEY WORDS: Uracil, Coordination compounds, Non-isothermal kinetic parameters, Elemental analysis, Spectral studies, Biological efficiency Bull. Chem. Soc. Ethiop. 2023, 37(4), 945-957. DOI: https://dx.doi.org/10.4314/bcse.v37i4.11

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Synthesis, structural, biological applications, DFT, molecular docking studies on Fe(III), Co(II), and Ni(II) complexes incorporating 2‐(pyridin‐2‐yl)phenol and 1H‐benzimidazole‐2‐carboxylic acid

Khalaf,

Abd El‐Lateef,

Abdou

2024

Applied Organom Chemis

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This study provides a detailed investigation into the synthesis, characterization, and biological activities of the coordination compounds FePPHBZC, CoPPHBZC, and NiPPHBZC. These compounds were synthesized with high yields by reacting chloride salts of Iron, Cobalt, or Nickel with 2‐(pyridin‐2‐yl)phenol (PPH) and 1H‐benzimidazole‐2‐carboxylic acid (BZC) in a 1:1:1 ratio. Various techniques including spectroscopic (IR, UV–vis, mass spectra), elemental analysis, conductivity, magnetic, and thermal analyses confirmed the formation and structure of these coordination compounds. Density functional theory (DFT) calculations were used to study their electronic structure, stability, and reactivity. 3D modeling revealed hexacoordinated geometries for Fe and Co complexes and a tetrahedral coordination for the Ni complex. Analysis of the highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO), and other reactivity parameters indicated changes in reactivity upon metal coordination. Molecular Electrostatic Potential (MEP) diagrams identified electron‐rich areas prone to nucleophilic attack, important for protein interactions during docking studies. Biological evaluations demonstrated that metal–ligand complexes exhibit enhanced antimicrobial, antioxidant, and anti‐inflammatory activities compared to individual ligands, with larger inhibition zones and higher inhibitory activity. Molecular docking studies showed strong interactions between metal–ligand complexes and target proteins, suggesting potential therapeutic applications. Among them, FePPHBZC exhibited the strongest interactions, followed by CoPPHBZC and NiPPHBZC, characterized by hydrogen bonding, ionic interactions, and other non‐covalent interactions, contributing to their enhanced stability and binding affinity.

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Synthesis, Characterization, and Bacterial Activity of Co(II), Ni(II), and Pd(II) Complexes with Ligands of Thymine, Uracil Thiuram Disulfur, and Cyclic Amines

Cited by 4 publications

References 20 publications

املاح الفلزات الانتقالية الأولى للدايازونيوم المشتق من مركب حلقي غير متجانس للنيتروجين تحضيرو تشخيص و الفعالية الحيوية

املاح الفلزات الانتقالية الأولى للدايازونيوم المشتق من مركب حلقي غير متجانس للنيتروجين تحضيرو تشخيص و الفعالية الحيوية

Complexation of some alkaline earth metals with bidentate uracil ligand: Synthesis, spectroscopic and antimicrobial analysis

Synthesis, structural, biological applications, DFT, molecular docking studies on Fe(III), Co(II), and Ni(II) complexes incorporating 2‐(pyridin‐2‐yl)phenol and 1H‐benzimidazole‐2‐carboxylic acid

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