Synthesis, characterization and bioactivity investigation of bioglass/hydroxyapatite composite

Preparation of Deproteinized Human Bone and Its Mixtures with Bio-Glass and Tricalcium Phosphate - Innovative Bioactive Materials for Skeletal Tissue Regeneration

“…In view of these findings, attempts to design composites that combine this biomaterial with markedly more biologically active bio-glass propose an interesting solution. Such a composite can stimulate osteogenesis, leading to the rapid formation of new skeletal tissue around the implant (Yuan et al, 2001;Ravarian et al, 2010). Biological tests of SiO 2 -CaO-Mg/natural HAp (bovine bone) composite obtained by means of thermal plasma processing have confirmed its lack of toxicity.…”

“…Amongst various methods of synthesis, the advantages of the chemical sol-gel method are worth noting. This technique enables material whose biological activity is greater than products manufactured using other processing methods to be obtained (Ravarian et al, 2010). Moreover, the sol-gel method does not require high temperature processing.…”

“…Numerous clinical trials, supported by the results of histological observations, have confirmed complete biotolerance to hydroxyapatite ceramic, as well as its positive effects on the process of bone healing and reconstruction. Additionally, hydroxyapatite ceramic can initiate and stimulate various processes that are associated with bone formation (Bellucci et al, 2011;Ravarian et al, 2010;Yuan et al, 2001). Contact between bioactive ceramic and living skeletal tissue induces osteogenesis.…”

Bioactive Ceramics as Bone Morphogenetic Proteins Carriers

“…Melting and sol-gel processing are two methods for producting glasses. Sol-gel processing has been successfully used in the production of a variety of materials for both biomedical and nonbiomedical applications (Hench, 2006;Ravarian et al, 2010). Sol-gel processing, an alternative to traditional melt processing of glasses, involves the synthesis of a solution (sol), typically composed of metal-organic and metal salt precursors followed by the formation of a gel by chemical reaction or aggregation, and lastly thermal treatment for drying, organic removal, and sometimes crystallization (Saravanapavan & Hench, 2003).…”

Porous HA/Alumina composites intended for bone-tissue engineering

“…The HA matrix was reinforced with ceramic-oxide constituents such as zirconia, titania, silica, yttria, bioglass or alumina. 3,6,[12][13][14][15][16][17][18] Alumina oxide is a cost-effective and well-accessible option for enhancing HA properties, especially the mechanical properties. The mechanical strength of a porous human bone is in a range of 2-12 MPa.…”