Synthesis, Characterization and Biological Activities of Some Metal Complexes Derived from Azo Dye Ligand 2-[2'-(5-Methyl thiazolyl)azo]-5-dimethylamino Benzoic Acid

Abstract

In this paper we report the synthesis and identification of Ni(II), Cu(II) and Zn(II) complexes with new thiazole based azo dye 2-[2'-(5-methyl thiazolyl)azo]-5-dimethyl amino benzoic acid (5-MeTAMB) by the diazotization of 2-amino-5-methyl thiazole and coupling with 3-dimethyl amino benzoic acid in alkaline alcoholic solution. The structures of the azo dye ligand and its metal complexes were confirmed by various analytical techniques like by elemental analysis (C.H.N.S), UV-visible, FT-IR spectroscopic, mass spectroscopic, Asian Journal of Chemistry; Vol. 30, No. 7 (2018), 1537-1545 microbial activities such as antibacterial [17], antiviral [18] and antifungal [19]. In this work describe the preparation and characterization of new thiazolylazo ligand (5-MeTAMB) and its complexes with Ni(II), Cu(II) and Zn(II) ions, is described biological activities (antibacterial and antifungal). The thiazolylazo ligand and its Cu(II) complex evaluated for in vitro anticancer activity against human breast cancer MCF7 by MTT assay. EXPERIMENTALAll the chemicals and solvents were of the highest purity obtained from BDH, Aldrich, sigma and Merck. Mass spectra was obtained using a Shimadzu Agilent Technologies 5973C at 70 e and MSD energy using a direct insertion probe (Acq method 10 W energy) at temperature 90-110 °C.

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“…The azo dye ligand was synthesized to use it in the same method [18,19] with some modifications. 6-methylbenzo[d]thiazol-2-amine (1.64 g, 0.01 mol) was mixed with 3 mL of HCl, and 20 mL distilled water and diazotized below 4 °C with NaNO2 (0.75 g, 0.01 mol), dissolved in 35 mL.…”

Synthesis, spectral properties and antibacterial studies of new hetrocyclic schiff-azo ligand derived from 5-amino 2-phenyl.4h-pyrazol-3-one with some transition metal complexes

“…The influence of the pH of the complex solutions was also studied at pH range (3)(4)(5)(6)(7)(8)(9)(10). To evaluated the optimum pH value from the illustrated in the Table (3) and Figures (1)(2)(3)(4)(5)(6)(7) which explained the relationship between pH value and the absorption values in ions solutions with the ligand (HMABP) used in this study, the determine pH depended on the fix absorption values at constant concentration for each solution.…”

“…Prominent medications which contain loop of pyrazole are silicoxib and activated steroids. New compounds of pyrazolone are of outstanding copolymerization and undergo on rinse in organic solvents in the case of using them for eyes (3) .…”