Synthesis, Characterization and Biological Activity of Organotin Derivatives of 2-Thionaphthalene, Including the Crystal Structures of (Naphthalenethiolato-S)triphenyltin(IV) and Bis(naphthalenethiolato-S)dimethyltin(IV)

Kalsoom, Abida; Mazhar, M.; Ali, Saqib; Mahon, Mary F.; Molloy, Kieran C.; Chaudry, M. Iqbal

doi:10.1002/(sici)1099-0739(199701)11:1<47::aid-aoc538>3.3.co;2-p

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“…1 -4 Recently, attention has been paid to the coordination chemistry of polydentate ligands that incorporate both thiol sulfur and heterocyclic nitrogen donor sites because of their unusual geometries and moderate biological activities against various bacteria and fungi. 5 In this regard, the most studied systems are the proligands, 2-mercaptopyridine (HSPy), R 2 Sn(SPy) 2 and R 2 SnCl(SPy), which have been characterized in solid state and in solution. 6 And some five-coordinated pyridine oxide complexes such as a square pyramidal, R 3 SnCl(SpyO), and a trigonalbipyramidal, R 2 SnCl 2 (PyO), have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Syntheses and crystal structures of diorganotin(IV) bis(2‐pyridinethiolato‐N‐oxide) complexes

Zhang

2003

Applied Organom Chemis

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(3) are synthesized and characterized by elemental analyses, IR, 1 H, 13 C, 119 Sn NMR spectroscopy, and their structures are determined by X-ray crystallography. In complex 1 the coordination geometry at tin is a skewtrapezoidal bipyramid, with cis-S,S and cis-O,O atoms occupying the trapezoidal plane and two n-butyl groups occupying the apical positions, which also exhibits strong π -π stacking interactions. In complexes 2 and 3 the geometry at tin is distorted cis-octahedral, with cis-O,O and cis-C,C atoms occupying the equatorial plane and trans-S,S atoms occupying the apical positions. Their in vitro cytotoxicity against two human tumour cell lines, MCF-7 and WiDr is reported. The ID 50 values found are comparable to those found for cis-platin, but lower than for many other diorganotin compounds.

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Section: Introductionmentioning

confidence: 99%

Syntheses and crystal structures of diorganotin(IV) bis(2‐pyridinethiolato‐N‐oxide) complexes

Zhang

2003

Applied Organom Chemis

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Synthesis, Characterization and Biological Activity of Organotin Derivatives of 2-Thionaphthalene, Including the Crystal Structures of (Naphthalenethiolato-S)triphenyltin(IV) and Bis(naphthalenethiolato-S)dimethyltin(IV)

Cited by 1 publication

References 0 publications

Syntheses and crystal structures of diorganotin(IV) bis(2‐pyridinethiolato‐N‐oxide) complexes

Syntheses and crystal structures of diorganotin(IV) bis(2‐pyridinethiolato‐N‐oxide) complexes

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