Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide

Abdulghani, Ahlam Jameel; Abbas, Nada M.

doi:10.1155/2011/706262

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…On the other hand, Inorganic elements play crucial role in biological and biological medical processes, and it is evident that many organic compounds used in medicine do not have a purely organic mode of action, some of them are activated or bio transformed by metal ions metabolism. Many drugs possess modified toxicological and pharmacological properties in the form of metal complex and probably Schiff bases are versatile C=N (imine) containing compounds possessing broad spectrum of biological activity and incorporation of metals in the form of complexes showed some degree of antibacterial, antifungal, antitumor, anticancer and anti-inflammatory activity [4][5][6][7][8]. In vivo studies have indicated that some biologically active compounds may become more carcinostatic and bacteriostatic upon chelation [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization with Antimicrobial Activity Studies on some Transition Metal Complexes of N, O Donor Novel Schiff Base Ligand

Hossain

Zakaria²,

Zahan

2017

J. Sci. Res.

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Metal complexes of Mn(II), Fe(II), Co(II) and Cd(II) ions with Schiff base ligand 4-{(pyridin-2-ylimino)methyl}phenol derived from condensation of 2-amino pyridine with 4-hydroxybenzaldehyde was prepared. The ligand and complexes were isolated from the reaction in the solid form and characterized by conductivity, magnetic moment, TLC, IR, UV-Visible, thermal analysis and some physical measurements. During complexation reaction with transition metal ions Schiff base act as a deprotonated tridentate ligand and IR spectra showed that N and O atoms are coordinated to the central metal atom. The observed values confirmed that the complexes have octahedral geometry. The Schiff base and its metal complexes have been found to have moderate to strong antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization with Antimicrobial Activity Studies on some Transition Metal Complexes of N, O Donor Novel Schiff Base Ligand

Hossain

Zakaria²,

Zahan

2017

J. Sci. Res.

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“…This is due to the coordination of the metal ion with the ligand. The spectra of complexes demonstrated new band vibrational modes to the M-N, M-S, and M-Cl group frequencies as a result of bonding the metal ion with the ligand L1Ni for νM-N 532, νM-S 422, and νM-Cl 337 as well as L1AgνM-N 532, νM-S 447, and L1Pd for νM-N 516, νM-S 400, and νM-Cl 333 [12], [18], [19], [20], [21], [22], [23]. The FTIR spectra for the compounds L1, L1Ni, L1Ag, and L1Pd are demonstrated in Figure 3.…”

Section: Infrared Spectra (Ft-ir) For the Free Ligand (L1) And Itsmentioning

confidence: 99%

Fabrication of Solar Cells Using Novel Micro- and Nano-Complexes of Triazole Schiff Base Derivatives

Ali¹,

Al-Hassani²,

Hussain³

et al. 2019

Journal of Southwest Jiaotong University

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A new asymmetrical Schiff base triazole ligand, (4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol) (L1), was synthesized and characterized using CHNS elemental analysis and FTIR, UV/Vis, mass, 1H NMR, and 13C NMR spectroscopies. The Schiff base metal complexes of NiL1, PdL1, and AgL1 were synthesized and identified using FTIR, UV/Vis and flame atomic absorption spectroscopies and elemental analysis, as well as magnetic susceptibility and conductivity measurements. NanoL1 and its complexes, nanoNiL1, nanoPdL1, and nanoAgL1, were prepared as compounds using ultrasound. The new nano-complexes were characterized using FTIR, UV/Vis, atomic force microscopy, scanning electron microscope, and XRD measurements. The structural, optical and morphological properties were studied in a solution of DMSO and then precipitated on silicon slides using the drop-casting method to fabricate the solar cells.

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“…The four heterocyclic ligands were attached to each of the four metal complexes. Only the copper complexes (57d) displayed potent cytotoxicity against Artemis salina (LD 50 Other new isatin-metal complexes include Schiff and Mannich base ligands coordinated to metal salts such as Co(II), Ni(II), Mn(II) and Ir(III) [141]. The complexes were evaluated against the Hep-2 larynx carcinoma cell line and the Ir(III) complex 58 (Fig.…”

Section: Metal Complexesmentioning

confidence: 99%

Recent Highlights in the Development of Isatin-Based Anticancer Agents

Vine¹,

Matesic²,

Locke³

et al. 2013

Advances in Anticancer Agents in Medicinal Chemistry

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Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from either mono-, di-, and trisubstitution of the aryl ring A, and/or those obtained by derivatisation of the isatin nitrogen and C2/C3 carbonyl moieties. These compounds inhibit cancer cell proliferation and tumour growth via interaction with a variety of intracellular targets such as DNA, telomerase, tubulin, P-glycoprotein, protein kinases and phosphatases. Herein we review recent highlights in the development of isatin-based compounds as anticancer agents with a particular focus on the cytotoxicity and structure activity relationships. Abstract:Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from either mono-, di-, and tri-substitution of the aryl ring A, and/or those obtained by derivatisation of the isatin nitrogen and C2/C3 carbonyl moieties. These compounds inhibit cancer cell proliferation and tumour growth via interaction with a variety of intracellular targets such as DNA, telomerase, tubulin, Pglycoprotein, protein kinases and phosphatases. Herein we review recent highlights in the development of isatin-based compounds as anticancer agents with a particular focus on the cytotoxicity and structure activity relationships.

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Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide

Cited by 21 publications

References 37 publications

Synthesis and Characterization with Antimicrobial Activity Studies on some Transition Metal Complexes of N, O Donor Novel Schiff Base Ligand

Synthesis and Characterization with Antimicrobial Activity Studies on some Transition Metal Complexes of N, O Donor Novel Schiff Base Ligand

Fabrication of Solar Cells Using Novel Micro- and Nano-Complexes of Triazole Schiff Base Derivatives

Recent Highlights in the Development of Isatin-Based Anticancer Agents

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