Synthesis, Characterization, and Biological Activity of Nickel (II) and Palladium (II) Complex with Pyrrolidine Dithiocarbamate (PDTC)

Islam, Sk Imadul; Das, Suvendu Bikash; Chakrabarty, Sutapa; Hazra, Sudeshna; Pandey, Akhil; Patra, Animesh

doi:10.1155/2016/4676524

Cited by 11 publications

(4 citation statements)

References 17 publications

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“…The complexes at (1456 and 1387) cm -1 are due to a characteristic band υ(C-N); this band denotes the carbon-nitrogen bond order intermediate between a single bond. Thus, metal shows the coordination of nitrogen with ions [35]. Similarly, the peak at 1240 cm -1 and 1230 cm -1 are due to υ(C-O) [36,37].…”

Section: Properties Of the Complexesmentioning

confidence: 91%

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

Dev

Sahu

Chaudhary

et al. 2023

J. Nepal Chem. Soc.

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The two new novel heteroleptic complexes of the type [M(II)L1.L2] (M= Zr(II) & Pd(II), L1= oxytetracycline (Otc), and L2=salicylaldehyde (Sal)) have been synthesized and analyzed by physical measurements such as CHN, pH, and conductivity. The conductivity data revealed the electrolytic nature of Pd(II)Otc/Sal and the non-electrolytic nature of the Zr(II)Otc/Sal metal complex of mixed ligand. The structural characterizations of the metal complex were approved by spectroscopic analysis methods, such as IR, 1H & 13C-NMR, UV/ Visible, and ESI-MS studies. Thermal analysis (TGA/DTA) determines the thermal and kinetic stabilities of the metal complexes using a popular Coats-Redfern equation through which the activation parameters can be calculated easily. SEM can determine the surface morphology of metal complexes. The selected bond lengths, bond angles, final optimized energy, and geometry of complexes were obtained by running an optimization task in the 3D molecular modeling software program via Chem 3D Pro. 12.0.2. The final geometrical energy was found to be 921.7712 for Zr(II)Otc/Sal and 914.6006 Kcal/mol for Pd(II)Otc/Sal complexes. Based on the above study, Zr(II)Otc/Sal complex has tetrahedral geometry and the Pd(II)Otc/Sal complex has square planar geometry. The complexes were tested in vitro for antibacterial susceptibility study against various strains of clinical pathogenic bacteria such as Staphylococcus aureus (Gram-positive), Proteus mirabilis, and Escherichia coli (Gram-negative). For the antibacterial study, the Kirby-Bauer paper disc diffusion technique is applied by using 50, 25, and 12.5 μg/μL concentrations of the metal complex. Good antibacterial sensitivity was found against all tested pathogens in all synthesized complexes.

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Section: Properties Of the Complexesmentioning

confidence: 91%

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

Dev

Sahu

Chaudhary

et al. 2023

J. Nepal Chem. Soc.

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“…The result showed higher antibacterial activity of compounds than the ligand [70]. Bis-(N-methyl-N-phenyl dithiocarbamate) complex of Ni(II) has been synthesized and screening against various Gram-positive and Gram-negative bacterial strains showed that the complex possessed antibacterial activity [71].…”

Section: Journal Of Applied Science and Education (Jase) A2z Journalsmentioning

confidence: 99%

Biological Applications of Metal Complexes of Dithiocarbamates

Maurya

Bajpai

2022

J. Appl. Sci. Educ.

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Dithiocarbamates are organosulphur ligands and form chelate compounds with metals. Their uses are reported in the field of accelerating vulcanization, pesticide, material science, organic synthesis, etc. Recent research demonstrated the potential of metal complexes of these ligands as good antifungal, antibacterial, and antitumor agents. Dithiocarbamate complexes have also been reported to use as a plasmonic sensor, as an inhibitor of proteasome, and for antioxidant and antileishmanial activity. This brief review presents the biological activities of metal complexes of dithiocarbamate.

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“…[46] The apparent association constant K app with determined using the Benesi-Hildebrand equation. [49] 1…”

Section: Bsa Binding Studiesmentioning

confidence: 99%

Investigation on CT‐DNA and Protein Interaction of New Pd(II) Complexes Involving Ceftazidime and 3‐Amino‐1,2,3‐triazole: Synthesis, Characterization, Biological Impact, Anticancer Evaluation, and Molecular Docking Approaches

Seddik,

Shoukry,

Rashidi

et al. 2023

Chemistry & Biodiversity

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Two new palladium (II) complexes, [Pd(CAZ)(OH2)2]2+ (1) and [Pd(3‐AT)(OH2)2]2+ (2), (CAZ=ceftazidime, and 3‐AT=amitrole) were synthesized and studied for their potential as anticancer drugs with low toxicity and high potency. To fully characterize these complexes, we conducted elemental analysis and FT‐IR studies. Furthermore, we irradiated the complexes with Indian 60Co gamma rays and thoroughly evaluated their antimicrobial properties. Our results demonstrate that the inhibitory activity of complexes was significantly enhanced against (G+) bacteria and fungi. Additionally, we probed the complexes' interaction with CT‐DNA and BSA using various techniques, including UV‐vis spectroscopy, thermal denaturation, viscometry, gel electrophoresis, and molecular docking studies. Our findings conclusively demonstrate that these complexes possess a strong binding interaction with CT‐DNA via minor groove binding and/or electrostatic interactions, as well as excellent binding affinity to BSA. Finally, we conducted a cytotoxicity assay that clearly indicates these complexes hold immense promise as cell growth inhibitors against MCF‐7 and HCT‐116.

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Synthesis, Characterization, and Biological Activity of Nickel (II) and Palladium (II) Complex with Pyrrolidine Dithiocarbamate (PDTC)

Cited by 11 publications

References 17 publications

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

Biological Applications of Metal Complexes of Dithiocarbamates

Investigation on CT‐DNA and Protein Interaction of New Pd(II) Complexes Involving Ceftazidime and 3‐Amino‐1,2,3‐triazole: Synthesis, Characterization, Biological Impact, Anticancer Evaluation, and Molecular Docking Approaches

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