Synthesis, characterization and biological activity of some mixed complexes of Cu(II) and Zn(II) with antibiotics of the nalidixic acid family and NN ligands.

Mendoza-Dı́az, Guillermo; Garciá-Nieto, R.M.; Gracia-Mora, Isabel; Arias-Negrete, Sergio; Ruiz-Ramı̀rez, Lena; Cosenza, I.L.; Ireta, Joel; Moreno‐Esparza, Rafael; Pannell, Keith H.; Cervantes‐Lee, Francisco

doi:10.1016/0162-0134(91)84611-c

Cited by 5 publications

(1 citation statement)

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“…Over the last two decades, copper-based compounds have had a strong biological impact, and copper, as one of the most important biological trace elements, plays a crucial role in anticancer agents [52,53]. Nano ionization is a common modern strategy for overcoming this constraint, and it's also likely to be a targeted solution toward cancer cell growth.…”

Section: Anticancer Activitymentioning

confidence: 99%

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal¹,

Nivetha

Sundar³

et al. 2021

Heliyon

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The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physicochemical properties of Wt extract mediated synthesized CuNPs (Wt-CuNPs). The Wt-CuNPs synthesized was found to be monodispersed and spherical, with an average size of 15 nm. Gas chromatography and mass spectrometry (GC-MS) research revealed that the Wt R.Br plant extract contains various phytochemical compounds. The properties of Wt-CuNPs were verified by the findings of characterization tests. Via in silico molecular docking experiments with established targets, the underlying mechanisms of cytotoxicity against breast cancer and larvicidal behaviour against Aedes aegypti of Wt-CuNPs were investigated. Interestingly, in vitro cytotoxicity studies showed 50% cell death (IC 50 ) of Wt-CuNPs treated MCF-7 cells and Vero Cells (Kidney epithelial cells) were displayed at 119.23 μg.mL À1 and 898.75 μg.mL À1 , respectively. Also, Wt-CuNPs showed least LC 50 and LC 90 values for larvicidal activity against A. aegypti were of 32.10 μg.mL À1 and 21.70 μg.mL À1 , respectively. Furthermore, Wt-CuNPs is found to be less toxic and biocompatible in haemolytic assays. The findings clearly showed that biosynthesized Wt-CuNPs have been used as a possible anticancer and larvicidal agent, as well as being environmentally friendly.

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Section: Anticancer Activitymentioning

confidence: 99%