Synthesis, characterization and biological evaluation studies of Cu(II) and Zn(II) complexes with gly-o-andn or gly-p-andn as primary ligand and N, N' donors as secondary ligand

Abstract

Metal complexes with heterocyclic Schiff bases are of substantial curiosity for the chemists. Ligand modifications are easily accessible due to preparative simplicity, structural variability and tunable electronic properties. Hetero atoms like N and O when incorporated in Schiff bases play a key role at binding sites in metallobiomolecules Transition metals form an integral part of biological system and their mixed ligand complexes with Schiff bases have established their remarkable application in biocidal fields as antibacterial, antifungal, antiinflammatory and as anticancerous agents. Keeping in mind their marked biological activity, this work reports the synthesis and characterization of mixed ligand complexes of zinc and copper with Schiff base (obtained by the condensation of glyoxal with ortho and para anisidine) as primary and N, N’ donor molecules as secondary ligands.