Synthesis, characterization and biological evaluation of some novel 2-substituted mercaptobenzimidazole derivatives.

Reddy, M. Sreenivasa; Anisetti, Ravinder Nath; Prasad, K. Durga; Sannigrahi, Santanu; Reddy, P. Arvinda

doi:10.1007/s11094-011-0537-7

Cited by 8 publications

(1 citation statement)

References 13 publications

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“…In another study, compounds 176–177 exhibited most prominent antiulcer activity against pylorus ligation-induced, aspirin induced, and ethanol induced ulcer in rat model at a dose level of 10 and 20 mg/kg compared to omeprazole ( Patil et al, 2010 ). Besides, Reddy et al ( Reddy et al, 2011 ) prepared a series of 2-substituted mercaptobenzimidazole derivatives and reported that compounds 178–180 produced notable antiulcer potentiality at a dose level of 10 mg/kg comparable to omeprazole. Furthermore, compound 181 prevented H + /K + -ATPase enzymatic activity with an IC 50 value of 1.6 × 10 –5 M and compound 182 displayed prominent effects on inhibition of gastric lesions and gastric acid secretion in a dose dependant manner (0.3–30 mg/kg) ( Tanaka et al, 2011 ; Yan et al, 2011 ).…”

Section: Biological Activitiesmentioning

confidence: 99%

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

et al. 2021

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Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent. Due to their isostructural pharmacophore of naturally occurring active biomolecules, benzimidazole derivatives have significant importance as chemotherapeutic agents in diverse clinical conditions. Researchers have synthesized plenty of benzimidazole derivatives in the last decades, amidst a large share of these compounds exerted excellent bioactivity against many ailments with outstanding bioavailability, safety, and stability profiles. In this comprehensive review, we have summarized the bioactivity of the benzimidazole derivatives reported in recent literature (2012–2021) with their available structure-activity relationship. Compounds bearing benzimidazole nucleus possess broad-spectrum pharmacological properties ranging from common antibacterial effects to the world’s most virulent diseases. Several promising therapeutic candidates are undergoing human trials, and some of these are going to be approved for clinical use. However, notable challenges, such as drug resistance, costly and tedious synthetic methods, little structural information of receptors, lack of advanced software, and so on, are still viable to be overcome for further research.

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Section: Biological Activitiesmentioning

confidence: 99%

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

et al. 2021

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Alkylation and Aminomethylation of 1,3-Dihydro-2Н-Benzimidazole-2-Thione

Bespalov

Gorchakova

Ivanov

et al. 2015

Chem Heterocycl Comp

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Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI

Farahat

Bennett-Vaughn

Mineva

et al. 2016

Bioorganic & Medicinal Chemistry Letters

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A series of novel benzimidazole diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a-c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines (15a-c). The new amidines were evaluated in vitro against the protozoan parasite Trypanosoma brucei rhodesiense (T. b. r.). The thiophene analogue 5b and the N-methyl compound 15a showed superior antitrypanosomal activity compared to that of the parent I.

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Synthesis, characterization and biological evaluation of some novel 2-substituted mercaptobenzimidazole derivatives.

Cited by 8 publications

References 13 publications

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

Alkylation and Aminomethylation of 1,3-Dihydro-2Н-Benzimidazole-2-Thione

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI

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