Synthesis, Characterization and Biological evaluation of Co (II) complex of 1-(2,4-dihydroxyphenyl) ethanone Semicarbazone

Abstract

In this heterocyclic base adduct of cobalt (II) complex have been synthesized by the reaction of cobalt (II) chloride with 1-(2,4-dihydroxyphenyl) ethanone Semicarbazone. The synthesized 2,4-dihydroxy acetophenone, 1-(2,4-dihydroxyphenyl) ethanone Semicarbazone and its cobalt complex has been characterized by physical constant, TLC and IR spectral data. All the target compounds exhibit growth inhibitory activity against E.Coli, and S.Aureus bacteria studied by agar well diffusion method. It is observed that activity depends upon strain and structure. All the synthesized compounds have good to moderate antimicrobial activity.