Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents

Synthesis of N-(6-Arylbenzo[d]thiazole-2-acetamide Derivatives and Their Biological Activities: An Experimental and Computational Approach

“…It was concluded that the potent antibacterial activities of these compounds might be due to electron withdrawing groups present on the aryl moiety in N-protected benzothiazole molecule. Similar observations are also reported by other groups which suggest that the presence of electron releasing and electron withdrawing groups substantially affects the antibacterial activity [33]. The results show that the benzothiazole compounds 3a-3h exhibit higher activities than the standard against some species.…”

Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex

“…Many biologically active thiourea-based (carboxamide) compounds have been reported possessing antibacterial [1][2][3] , antifungal 4,5 , anticancer 6,7 , antiviral 8 , pesticidal 9 , cytotoxic 10 , herbicidal 11 and insecticidal 12 activities. Thiourea derivatives have been effectively used in organocatalysis 13 and as curing agents for epoxy resins.…”

Experimental and DFT Investigation on the Influence of Electron Donour/Acceptor on the Hydrogen Bonding Interactions of 1-(1,3-Benzothiazol-2-yl)-3-(R-benzoylthiourea)

“…In addition, stretching vibration for C=N from the benzoyl ring can be found at 1510-1525 cm -1 and the band at 2912-3003 cm -1 indicates the presence of C-H from the benzoyl ring. The stretching frequencies of C=O were relatively lower than a free C=O (< 1730 cm -1 ) due to the formation of hydrogen bond (Saeed et al 2010;Yusof et al 2010). The functional groups and their vibration frequencies for BBT, BBT-4Cl, and BBT-4OCH 3 are collected in Table 1.…”