Synthesis, Characterization, and Biological Evaluation of Osmium(IV) Pyrazole Carbothioamide Complexes

Pursuwani, Bharat H.; Bhatt, Bhupesh S.; Vaidya, Foram U.; Pathak, Chandramani; Patel, Mohan N.

doi:10.1080/10406638.2020.1852581

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…HEX software is widely used for in silico docking studies of metal complexes (Cu(II), Co(II), Ni(II), Zn(II), and Os(IV)), as it maintains the structural conformation during docking. 77 125 Docking of metallodrugs has posed difficulties when dealing with the formation of coordination bonds between the metal and a donor of an amino acid side chain. Many docking programs (e.g., GOLD and AutoDock) have limitations, as the covalent docking approach is used.…”

Section: Computational Studiesmentioning

confidence: 99%

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Ngoepe

Clayton

2021

Pharmaceutical Fronts

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Medicinal inorganic chemistry involving the utilization of metal-based compounds as therapeutics has become a field showing distinct promise. DNA and RNA are ideal drug targets for therapeutic intervention in the case of various diseases, such as cancer and microbial infection. Metals play a vital role in medicine, with at least 10 metals known to be essential for human life and a further 46 nonessential metals having been involved in drug therapies and diagnosis. These metal-based complexes interact with DNA in various ways, and are often delivered as prodrugs which undergo activation in vivo. Metal complexes cause DNA crosslinking, leading to the inhibition of DNA synthesis and repair. In this review, the various interactions of metal complexes with DNA nucleic acids, as well as the underlying mechanism of action, were highlighted. Furthermore, we also discussed various tools used to investigate the interaction between metal complexes and the DNA. The tools included in vitro techniques such as spectroscopy and electrophoresis, and in silico studies such as protein docking and density-functional theory that are highlighted for preclinical development.

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Section: Computational Studiesmentioning

confidence: 99%

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Ngoepe

Clayton

2021

Pharmaceutical Fronts

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“…35,36 Thiazole metal complexes are widely used in medicine, 37 optical materials, 38 and agriculture. 39 New antitumor drugs may be developed if aromatic carboxylic acid and thiazole are both used as ligands to synthesize copper(II) complexes. For extending this research area further, the synthesis of two new copper(II) complexes with ambt and 4-chloro-3-nitrobenzoic acid (cnba)/4-chlorobenzoic acid (clba) as ligands was reported in this paper.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures, DNA interactions, and antitumor activity of two new dinuclear copper(ii) complexes with thiazole ligand

Zeng

Cai

et al. 2021

RSC Adv.

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Synthesis, Characterization, and Biological Evaluation of Osmium(IV) Pyrazole Carbothioamide Complexes

Cited by 2 publications

References 47 publications

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Synthesis, crystal structures, DNA interactions, and antitumor activity of two new dinuclear copper(ii) complexes with thiazole ligand

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