Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Abd El-Lateef, Hany M.; Bafail, Duaa; Alhalees, Noura Hamdi Yousef; Toson, Eslam E. M.; Abu Almaaty, Ali H.; Elsayed, Elsherbiny H.; Zaki, Islam; Youssef, Magdy M.

doi:10.1039/d4ra03963g

RSC Adv.

2024

DOI: 10.1039/d4ra03963g

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Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Hany M. Abd El-Lateef,

Duaa Bafail,

Noura Hamdi Yousef Alhalees

et al.

Abstract: A sequence of novel 2-(quinoline-4-carbonyl)hydrazide scaffolds carrying the acrylamide moiety have been synthesized and evaluated for in vitro cytotoxicity against an MCF-7 breast cancer cell line.

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Cited by 2 publications

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Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Abd El-Lateef,

Alharbi,

Fayad

et al. 2025

Journal of Molecular Structure

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Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Abd El-Lateef,

Alharbi,

Fayad

et al. 2025

Journal of Molecular Structure

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Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies

Ryad,

Elmaaty,

Selim

et al. 2024

RSC Adv.

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Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Abstract: A sequence of novel 2-(quinoline-4-carbonyl)hydrazide scaffolds carrying the acrylamide moiety have been synthesized and evaluated for in vitro cytotoxicity against an MCF-7 breast cancer cell line.

Cited by 2 publications

References 43 publications

Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies

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