Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a  Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde

Mainsah, Evans N.; Ntum, Sally-Judith E.; Conde, Mariam Asseng; Chi-Tangyie, George; Raftery, James; Ndifon, Peter T.

doi:10.4236/csta.2019.84004

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Particularly, the strong v(C=N) vibrations in all compounds is a confirmation of the successful condensation reaction (imine bond formation) that lead to the hydrazones formation. This is in agreement with previous reports (Mainsah et al;2019, Ntum et al;2020, Moustafa et al;2022).…”

Section: Discussionsupporting

confidence: 94%

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Muhammad,

Ibrahim,

Ayo

et al. 2024

FJS

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N’-(2-pyridinylmethylene)nicotinohydrazide A, N’-(4-pyridinylmethylene)nicotinohydrazide B, N’-(2- ethoxybenzylidene)nicotinohydrazide C, N’-(4- ethoxybenzyldene)nicotinohydrazide D and N’-(2-hydroxyl-5-methoxybenzylidene)nicotinohydrazide E, was prepared by refluxing the ethanolic solution of nictonic acid hydrazide and ethanolic solutions of 2-pyridinrcarboxaldehyde, 4-pyridinecarboxaldehyde, 2-ethoxybenzaldehyde, 4-ethoxybenzaldehyde and 2-hydroxy-5-methoxybenzaldehyde in 1:1 mole ratio for 4 hours in a separate reactions. The compounds obtained had a melting point between (120-236 oC) and a percentage yield between (52.38-77.70 %). They were crystalline solids. The compounds' solubility were assessed in water, ethanol, methanol, acetone, hexane, diethyl ether, dimethyl sulfoxide (DMSO), ethyl acetate, and chloroform. The substances were discovered to be fully soluble in DMSO and methanol. FT-IR, 1H-NMR and 13C-NMR were used for the characterization of the compounds. The antibacterial and antifungal properties were tested against Methicillin-resistant Staphylococcus Aureus, Vancomycin-resistant Enterococci, S. aureus, S. typhi, P. aeruginosa, A. nigre, A. flavus, and C. albicans. The zones of inhibitions ranged from 22 to 28 mm and the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were found to be 0.063 mg/mL, 0.125 mg/mL and 0.125 mg/mL respectively. These indicated that the compounds might be good potential drug candidates.

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Section: Discussionsupporting

confidence: 94%

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Muhammad,

Ibrahim,

Ayo

et al. 2024

FJS

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“…The Co-O stretching vibration is evident at 643 cm -1 , providing information about the cobalt-oxygen bonding in the acetate complex [51,52]. Furthermore, the broad band at 3300-2800 cm -1 is attributed to H-bonded O-H stretching, which is like due to the presence of water molecules associated with cobalt acetate [53]. In the FTIR spectrum of PEG-capped Co3O4 nanoparticles, the peak at 652 cm -1 is associated with the Co-O stretching of Co 3+ ions trapped in the octahedral site, confirming the presence of cobalt oxide in the synthesized nanoparticles [54].…”

Section: Structural Studies Of Peg/ Co3o4 Via X-ray Diffraction (Xrd)mentioning

confidence: 99%

A Hybrid Synthesis Approach: Tailoring Photocatalytic Activity of Co3O4 Nanoparticles by PEG Functionalization

Kaur,

Kumar,

Kaur

et al. 2024

ajc

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This study presents a novel fusion of precipitation and hydrothermal methods for the synthesis of polyethylene glycol (PEG)-functionalized cobalt oxide (Co3O4) nanoparticles. The synthesized PEG/Co3O4 nanoparticles characterized using various techniques to elucidate their structure, composition, properties and application. The XRD analysis confirmed the formation of cubic phase of Co3O4 with a crystallite size of 2.04 nm. Two direct bandgap (Eg) transitions were observed at energy levels of 1.68 and 2.5 eV, exhibiting intensities that exceeded those reported in prior studies. The synthesized nanoparticles exhibited distinct structural features as revealed by FESEM and HRTEM investigations. Furthermore, the FTIR analysis provided evidence of interactions between PEG and Co3O4, suggesting successful functionalization. The high crystallinity of the PEG-mediated Co3O4 nanoparticles was further confirmed by the selected area electron diffraction (SAED) pattern. The XPS analysis revealed the presence of Co2+ and Co3+ ions, along with defect sites, confirming the successful synthesis of Co3O4 NPs with controlled oxidation states. These findings offer valuable insights into the chemical composition and electronic structure of the synthesized PEG-mediated Co3O4 nanoparticles. The photocatalytic activity of the PEG/Co3O4 nanoparticles was evaluated through the degradation of Congo red dye, a typical azo dye pollutant. The study revealed that PEG/Co3O4 (dose 200 mg L-1) acted as an efficient photocatalyst for Congo red degradation. These results suggest that PEG-mediated Co3O4 nanoparticles hold promising potential as efficient photocatalysts for the treatment of wastewater containing organic contaminants.

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“…Pyridine and its derivatives are used as an important ingredient in the manufacture of important commodities such as medicines [3], vitamins [4], food flavors [1], [5], pesticides [6], paints [7], dyes and pharmacophore [8,9], rubber products [10], adhesives [11], waterproof fabrics, and solvents [12]. The pyridine ring is found in many essential compounds, such as niacin and pyridoxal [13] which are build the structure of vitamin B, isoniazid [14], as well as other compound with antiviral, anti-HIV [15], anticancer, antitumor [2], antibacterial [16], antimalarial [17], anti-inflammatory [18], antidiabetic [19], and antioxidant properties [20]. The worldwide annual production of pyridine reached up to 20,000 tonnes per year [1].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics Theoretical Investigation for Synthesis of Pyridine from Pyrylium Salt using Density Functional Theory

Khoiriah

2023

J. Kartika Kimia

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Pyridine is a heterocyclic compound that is widely used as an ingredient in medicines, vitamins, food flavors, pesticides, dyes, adhesives, and others. Currently, pyridine synthesis is carried out with coal tar as a raw material, which is a non-renewable natural resource. In this research, a theoretical study was carried out to evaluate the synthesis process of pyridine using pyrylium salt as an alternative raw material to displace coal tar. This study also aims to simulate the pyridine synthesis and the energy required or released in the process. Density Functional Theory (DFT) method was employed to calculate some thermodynamic properties of the species involved in the reaction such as enthalpy, entropy, and Gibbs free energy in a vacuum and solvated model in order to study the progress of the reaction and mechanism. Based on the calculation results, the lowest value of enthalpy, entropy, and free energy Gibbs is obtained when the reaction takes place in a vacuum. The change of entropy and free Gibbs energy of the reaction was not predominantly affected by the degree of polarity of the solvent. Meanwhile, the enthalpy of reaction simulated in water solvent is higher than in the ethanol solvent. The synthesis reaction of pyridine from pyrylium salt is exothermic and exergonic because it has a negative value of enthalpy change and Gibbs free energy at 298.15 K, which is potential to be done at room temperature without extreme condition control.

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Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde

Cited by 7 publications

References 17 publications

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

A Hybrid Synthesis Approach: Tailoring Photocatalytic Activity of Co3O4 Nanoparticles by PEG Functionalization

Thermodynamics Theoretical Investigation for Synthesis of Pyridine from Pyrylium Salt using Density Functional Theory

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